| pubmed-article:11948466 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11948466 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:11948466 | lifeskim:mentions | umls-concept:C1516213 | lld:lifeskim |
| pubmed-article:11948466 | lifeskim:mentions | umls-concept:C0033325 | lld:lifeskim |
| pubmed-article:11948466 | lifeskim:mentions | umls-concept:C0032854 | lld:lifeskim |
| pubmed-article:11948466 | lifeskim:mentions | umls-concept:C0598034 | lld:lifeskim |
| pubmed-article:11948466 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:11948466 | lifeskim:mentions | umls-concept:C0681842 | lld:lifeskim |
| pubmed-article:11948466 | lifeskim:mentions | umls-concept:C1561558 | lld:lifeskim |
| pubmed-article:11948466 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:11948466 | pubmed:dateCreated | 2002-4-11 | lld:pubmed |
| pubmed-article:11948466 | pubmed:abstractText | The prognostic significance of BRCA2 mRNA levels in tumor tissues was studied in sporadic breast cancer patients. BRCA2 mRNA levels were determined by real-time PCR. Histologic grade III tumors showed significantly (p = 0.001) higher BRCA2 mRNA levels (0.828 +/- 0.102 BRCA2/beta-glucuronidase mRNA ratio, mean +/- SE) than histologic grade I and II tumors (0.438 +/- 0.055) and estrogen receptor (ER)-negative tumors (0.773 +/- 0.102) showed a nonsignificant (p = 0.072) trend toward an increase in BRCA2 mRNA levels compared to ER-positive tumors (0.541 +/- 0.079). Other clinicopathologic parameters, such as menopausal status, lymph node status and tumor size, were not significantly associated with BRCA2 mRNA levels. Patients with high BRCA2 mRNA levels showed a significantly (p = 0.006) lower 5-year disease free survival rate (63%) than those with low levels (94%). Lymph node metastases, ER negativity and high histologic grade were also significantly (p < 0.05) associated with poor prognosis. Multivariate analysis revealed that BRCA2 mRNA levels were a significant prognostic factor, being independent of the other conventional prognostic factors. Our results suggest that BRCA2 mRNA levels might serve as a clinically useful prognostic factor in breast cancer patients. | lld:pubmed |
| pubmed-article:11948466 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11948466 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11948466 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11948466 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11948466 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11948466 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11948466 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11948466 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11948466 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11948466 | pubmed:issn | 0020-7136 | lld:pubmed |
| pubmed-article:11948466 | pubmed:author | pubmed-author:MiyoshiYasuoY | lld:pubmed |
| pubmed-article:11948466 | pubmed:author | pubmed-author:TaguchiTetsuy... | lld:pubmed |
| pubmed-article:11948466 | pubmed:author | pubmed-author:TamakiYasuhir... | lld:pubmed |
| pubmed-article:11948466 | pubmed:author | pubmed-author:NoguchiShinza... | lld:pubmed |
| pubmed-article:11948466 | pubmed:author | pubmed-author:EgawaChiyomiC | lld:pubmed |
| pubmed-article:11948466 | pubmed:copyrightInfo | Copyright 2002 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:11948466 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11948466 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:11948466 | pubmed:volume | 98 | lld:pubmed |
| pubmed-article:11948466 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11948466 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11948466 | pubmed:pagination | 879-82 | lld:pubmed |
| pubmed-article:11948466 | pubmed:dateRevised | 2007-7-24 | lld:pubmed |
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| pubmed-article:11948466 | pubmed:meshHeading | pubmed-meshheading:11948466... | lld:pubmed |
| pubmed-article:11948466 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11948466 | pubmed:articleTitle | High BRCA2 mRNA expression predicts poor prognosis in breast cancer patients. | lld:pubmed |
| pubmed-article:11948466 | pubmed:affiliation | Department of Surgical Oncology, Osaka University Medical School, Osaka, Japan. | lld:pubmed |
| pubmed-article:11948466 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11948466 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11948466 | lld:pubmed |
