| pubmed-article:11927625 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11927625 | lifeskim:mentions | umls-concept:C0003451 | lld:lifeskim |
| pubmed-article:11927625 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:11927625 | lifeskim:mentions | umls-concept:C0162508 | lld:lifeskim |
| pubmed-article:11927625 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:11927625 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:11927625 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:11927625 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:11927625 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:11927625 | lifeskim:mentions | umls-concept:C1367731 | lld:lifeskim |
| pubmed-article:11927625 | lifeskim:mentions | umls-concept:C1334482 | lld:lifeskim |
| pubmed-article:11927625 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:11927625 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:11927625 | lifeskim:mentions | umls-concept:C1150587 | lld:lifeskim |
| pubmed-article:11927625 | lifeskim:mentions | umls-concept:C1705632 | lld:lifeskim |
| pubmed-article:11927625 | lifeskim:mentions | umls-concept:C0086982 | lld:lifeskim |
| pubmed-article:11927625 | lifeskim:mentions | umls-concept:C0205088 | lld:lifeskim |
| pubmed-article:11927625 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:11927625 | pubmed:dateCreated | 2002-4-2 | lld:pubmed |
| pubmed-article:11927625 | pubmed:abstractText | c-Jun NH(2)-terminal kinases (JNK) play important roles in T helper cell (Th) proliferation, differentiation, and maintenance of Th1/Th2 polarization. To determine whether JNKs are involved in antiviral T cell immunity, and whether JNK1 and JNK2 bear biological differences, we investigated the immune responses of JNK1-deficient and JNK2-deficient mice to lymphocytic choriomeningitis virus (LCMV). After LCMV infection, wild-type (JNK(+/+)) mice had a 5- to 10-fold increase in splenic CD8(+) T cells. In contrast, infected JNK1(-/-) mice showed a significantly lower virus-specific CD8(+) T cell expansion. However, JNK1(-/-) mice cleared LCMV infection with similar kinetics as JNK(+/+) mice. Splenic T cells from LCMV-infected JNK1(-/-) animals produced interferon gamma after stimulation with viral peptides. However, fewer JNK1(-/-) T cells acquired an activated phenotype (CD44(hi)) and more JNK1(-/-)CD8(+)CD44(hi) cells underwent apoptosis than JNK(+/+) cells at the peak of the primary response. In contrast, LCMV-infected JNK2(-/-) mice generated more virus-specific CD8(+) T cells than JNK(+/+) mice. These results indicate that JNK1 and JNK2 signal pathways have distinct roles in T cell responses during a viral infection. JNK1 is involved in survival of activated T cells during immune responses, and JNK2 plays a role in control of CD8(+) T cell expansion in vivo. | lld:pubmed |
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| pubmed-article:11927625 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11927625 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11927625 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11927625 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11927625 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11927625 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11927625 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:11927625 | pubmed:author | pubmed-author:DavisRoger... | lld:pubmed |
| pubmed-article:11927625 | pubmed:author | pubmed-author:FlavellRichar... | lld:pubmed |
| pubmed-article:11927625 | pubmed:author | pubmed-author:HomannDirkD | lld:pubmed |
| pubmed-article:11927625 | pubmed:author | pubmed-author:ArbourNathali... | lld:pubmed |
| pubmed-article:11927625 | pubmed:author | pubmed-author:NanicheDenise... | lld:pubmed |
| pubmed-article:11927625 | pubmed:author | pubmed-author:OldstoneMicha... | lld:pubmed |
| pubmed-article:11927625 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11927625 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11927625 | pubmed:volume | 195 | lld:pubmed |
| pubmed-article:11927625 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11927625 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11927625 | pubmed:pagination | 801-10 | lld:pubmed |
