| pubmed-article:11911970 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11911970 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11911970 | lifeskim:mentions | umls-concept:C0006826 | lld:lifeskim |
| pubmed-article:11911970 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:11911970 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:11911970 | lifeskim:mentions | umls-concept:C1135629 | lld:lifeskim |
| pubmed-article:11911970 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:11911970 | lifeskim:mentions | umls-concept:C1441616 | lld:lifeskim |
| pubmed-article:11911970 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:11911970 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11911970 | pubmed:dateCreated | 2002-3-25 | lld:pubmed |
| pubmed-article:11911970 | pubmed:abstractText | Crk is a signaling adaptor protein which is mostly composed of SH2 and SH3 domains, and has been shown to play a pivotal role in cell proliferation, differentiation, and migration. Because Crk was originally isolated as an avian sarcoma virus CT10 encoding oncoprotein v-Crk, we examined a potential role for c-Crk in the carcinogenesis of human cancers. First, to analyze gene mutations of c-Crk, we isolated a human bacterial artificial chromosome clone containing Crk genome and exon/intron structures. However, polymerase chain reaction-single strand conformation polymorphism methods failed to show any genomic mutations in the Crk exon which could be related to carcinogenesis. Second, immunohistochemical analysis of c-Crk-II demonstrated that the levels of c-Crk-II were significantly elevated in most of the tumors, particularly in the colon and lung cancers. Furthermore, immunoblot analysis using human lung cancer cell lines revealed that the expression levels of c-Crk-II were correlated to growth rates of cells. The elevated expression levels of c-Crk-II might be related to the development of human cancers. | lld:pubmed |
| pubmed-article:11911970 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11911970 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11911970 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11911970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11911970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11911970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11911970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11911970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11911970 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11911970 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11911970 | pubmed:issn | 0304-3835 | lld:pubmed |
| pubmed-article:11911970 | pubmed:author | pubmed-author:TanakaShinyaS | lld:pubmed |
| pubmed-article:11911970 | pubmed:author | pubmed-author:ShimizuMichio... | lld:pubmed |
| pubmed-article:11911970 | pubmed:author | pubmed-author:NagashimaKazu... | lld:pubmed |
| pubmed-article:11911970 | pubmed:author | pubmed-author:SawaHirofumiH | lld:pubmed |
| pubmed-article:11911970 | pubmed:author | pubmed-author:NishiharaHiro... | lld:pubmed |
| pubmed-article:11911970 | pubmed:author | pubmed-author:TsudaMasumiM | lld:pubmed |
| pubmed-article:11911970 | pubmed:author | pubmed-author:OikawaSumieS | lld:pubmed |
| pubmed-article:11911970 | pubmed:author | pubmed-author:MaedaMasaeM | lld:pubmed |
| pubmed-article:11911970 | pubmed:author | pubmed-author:ShinomiyaHiro... | lld:pubmed |
| pubmed-article:11911970 | pubmed:author | pubmed-author:TanigamiAkira... | lld:pubmed |
| pubmed-article:11911970 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11911970 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:11911970 | pubmed:volume | 180 | lld:pubmed |
| pubmed-article:11911970 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11911970 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11911970 | pubmed:pagination | 55-61 | lld:pubmed |
| pubmed-article:11911970 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11911970 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11911970 | pubmed:articleTitle | Molecular and immunohistochemical analysis of signaling adaptor protein Crk in human cancers. | lld:pubmed |
| pubmed-article:11911970 | pubmed:affiliation | Laboratory of Molecular and Cellular Pathology, Hokkaido University School of Medicine, N 15, W7, Kita-ku, Sapporo, Japan. | lld:pubmed |
| pubmed-article:11911970 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11911970 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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