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pubmed-article:11902864pubmed:dateCreated2002-3-20lld:pubmed
pubmed-article:11902864pubmed:abstractTextWe have been investigating a modular, threading DNA polyintercalator design based upon the 1,4,5,8-naphthalene tetracarboxylic diimide (NDI) intercalating unit. Previously, we have reported the NMR analysis of a bis-intercalator-DNA complex in which the peptide linker between NDI units was found to occupy the DNA major groove (Guelev, Lee, Sorey, Hoffman, Iverson, Chem. Biol. 2001, 8, 415-425). Here we describe the NMR analysis of a complex between a related bis-intercalator known to display altered DNA sequence specificity. In this case, the linker resides in the DNA minor groove. We have thus shown that within this set of sequence specific bis-intercalators, both DNA grooves can be accessed, setting the stage for longer threading polyintercalators designed to have linkers occupying both grooves in an alternating fashion.lld:pubmed
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pubmed-article:11902864pubmed:authorpubmed-author:IversonBrent...lld:pubmed
pubmed-article:11902864pubmed:authorpubmed-author:GuelevVladimi...lld:pubmed
pubmed-article:11902864pubmed:authorpubmed-author:SoreyStevenSlld:pubmed
pubmed-article:11902864pubmed:authorpubmed-author:HoffmanDavid...lld:pubmed
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pubmed-article:11902864pubmed:pagination2864-5lld:pubmed
pubmed-article:11902864pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:11902864pubmed:articleTitleChanging DNA grooves--a 1,4,5,8-naphthalene tetracarboxylic diimide bis-intercalator with the linker (beta-Ala)(3)-Lys in the minor groove.lld:pubmed
pubmed-article:11902864pubmed:affiliationDepartment of Chemistry and Biochemistry, The University of Texas at Austin, Austin, TX 78722, USA.lld:pubmed
pubmed-article:11902864pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11902864pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:11902864pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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