| pubmed-article:11897632 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11897632 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:11897632 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:11897632 | lifeskim:mentions | umls-concept:C0021851 | lld:lifeskim |
| pubmed-article:11897632 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11897632 | lifeskim:mentions | umls-concept:C0757457 | lld:lifeskim |
| pubmed-article:11897632 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:11897632 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:11897632 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:11897632 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:11897632 | pubmed:dateCreated | 2002-3-18 | lld:pubmed |
| pubmed-article:11897632 | pubmed:abstractText | Multidrug resistance-associated protein 3 (MRP3; symbol ABCC3), has been shown to mediate ATP-dependent transport of organic anions including 17beta-glucuronosyl estradiol, glucuronosyl bilirubin, monovalent, and sulfated bile salts. MRP3 mRNA expression was reported in rat intestine suggesting a role of MRP3 in the intestinal transport. We examined the expression and localization of MRP3 in rat small and large intestine by RT-PCR, immunofluorescence, and immunoblot analysis. MRP3 was identified in all intestinal segments by RT-PCR. MRP3 expression was low in duodenum and jejunum but markedly increased in ileum and colon. With the use of a rat MRP3 specific antibody, MRP3 was localized to the basolateral domains of enterocytes. Immunofluorescence analysis and immunoblot analysis confirmed a strong expression of rat MRP3 in ileum and colon. In contrast, MRP2 was predominantly expressed in the proximal segments of rat small intestine. Our findings demonstrate a high expression of rat MRP3 in ileum and colon and provide evidence for an involvement of MRP3 in the ATP-dependent transport of organic anions, including bile salts from the enterocyte into blood. | lld:pubmed |
| pubmed-article:11897632 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11897632 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11897632 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11897632 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11897632 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11897632 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11897632 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11897632 | pubmed:issn | 0193-1857 | lld:pubmed |
| pubmed-article:11897632 | pubmed:author | pubmed-author:SugiyamaYuich... | lld:pubmed |
| pubmed-article:11897632 | pubmed:author | pubmed-author:RostDanielD | lld:pubmed |
| pubmed-article:11897632 | pubmed:author | pubmed-author:MahnerSvenS | lld:pubmed |
| pubmed-article:11897632 | pubmed:author | pubmed-author:StremmelWolfg... | lld:pubmed |
| pubmed-article:11897632 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11897632 | pubmed:volume | 282 | lld:pubmed |
| pubmed-article:11897632 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11897632 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11897632 | pubmed:pagination | G720-6 | lld:pubmed |
| pubmed-article:11897632 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11897632 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11897632 | pubmed:articleTitle | Expression and localization of the multidrug resistance-associated protein 3 in rat small and large intestine. | lld:pubmed |
| pubmed-article:11897632 | pubmed:affiliation | Department of Gastroenterology, University of Heidelberg, 69115 Heidelberg, Germany. Daniel_Rost@med.uni-heidelberg.de | lld:pubmed |
| pubmed-article:11897632 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11897632 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:11897632 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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