| pubmed-article:11897163 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11897163 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:11897163 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:11897163 | lifeskim:mentions | umls-concept:C0037925 | lld:lifeskim |
| pubmed-article:11897163 | lifeskim:mentions | umls-concept:C0205527 | lld:lifeskim |
| pubmed-article:11897163 | lifeskim:mentions | umls-concept:C0243192 | lld:lifeskim |
| pubmed-article:11897163 | lifeskim:mentions | umls-concept:C0009014 | lld:lifeskim |
| pubmed-article:11897163 | lifeskim:mentions | umls-concept:C0531859 | lld:lifeskim |
| pubmed-article:11897163 | lifeskim:mentions | umls-concept:C1521797 | lld:lifeskim |
| pubmed-article:11897163 | lifeskim:mentions | umls-concept:C1152725 | lld:lifeskim |
| pubmed-article:11897163 | lifeskim:mentions | umls-concept:C0443254 | lld:lifeskim |
| pubmed-article:11897163 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:11897163 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11897163 | pubmed:dateCreated | 2002-3-18 | lld:pubmed |
| pubmed-article:11897163 | pubmed:abstractText | We examined the role of the spinal muscarinic receptor subtype in the anti-nociceptive effect of intrathecal (i.t.) alpha2 adrenoceptor agonist clonidine in mice. I.t. injection of the muscarinic receptor antagonist atropine completely inhibited i.t. clonidine-induced increase in the mechanical threshold, but did not affect the increase in tail-flick latency induced by i.t. clonidine. The clonidine-induced increase in mechanical threshold was inhibited by i.t. injection of the M1 receptor antagonist pirenzepine in a dose-dependent manner, and by the M3 receptor antagonist 4-DAMP, but not by the M2 receptor antagonist methoctramine. The potency of pirenzepine was greater than that of 4-DAMP. These results suggest that the clonidine-induced increase in mechanical threshold is mediated via the activation of M1 receptors in the spinal cord. | lld:pubmed |
| pubmed-article:11897163 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11897163 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11897163 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11897163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11897163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11897163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11897163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11897163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11897163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11897163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11897163 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11897163 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11897163 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11897163 | pubmed:issn | 0304-3940 | lld:pubmed |
| pubmed-article:11897163 | pubmed:author | pubmed-author:MoriyamaTomok... | lld:pubmed |
| pubmed-article:11897163 | pubmed:author | pubmed-author:HondaKenjiK | lld:pubmed |
| pubmed-article:11897163 | pubmed:author | pubmed-author:KogaKoheiK | lld:pubmed |
| pubmed-article:11897163 | pubmed:author | pubmed-author:KoguchiMasako... | lld:pubmed |
| pubmed-article:11897163 | pubmed:author | pubmed-author:TakanoYukioY | lld:pubmed |
| pubmed-article:11897163 | pubmed:author | pubmed-author:KamiyaHiro-oH... | lld:pubmed |
| pubmed-article:11897163 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11897163 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:11897163 | pubmed:volume | 322 | lld:pubmed |
| pubmed-article:11897163 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11897163 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11897163 | pubmed:pagination | 161-4 | lld:pubmed |
| pubmed-article:11897163 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:11897163 | pubmed:meshHeading | pubmed-meshheading:11897163... | lld:pubmed |
| pubmed-article:11897163 | pubmed:meshHeading | pubmed-meshheading:11897163... | lld:pubmed |
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| pubmed-article:11897163 | pubmed:meshHeading | pubmed-meshheading:11897163... | lld:pubmed |
| pubmed-article:11897163 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11897163 | pubmed:articleTitle | Intrathecal alpha2 adrenoceptor agonist clonidine inhibits mechanical transmission in mouse spinal cord via activation of muscarinic M1 receptors. | lld:pubmed |
| pubmed-article:11897163 | pubmed:affiliation | Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, 814-0180, Japan. khonda@fukuoka-u.ac.jp | lld:pubmed |
| pubmed-article:11897163 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11897163 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11897163 | lld:pubmed |
