| pubmed-article:11895806 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11895806 | lifeskim:mentions | umls-concept:C0249880 | lld:lifeskim |
| pubmed-article:11895806 | lifeskim:mentions | umls-concept:C0023452 | lld:lifeskim |
| pubmed-article:11895806 | lifeskim:mentions | umls-concept:C0085862 | lld:lifeskim |
| pubmed-article:11895806 | lifeskim:mentions | umls-concept:C1299583 | lld:lifeskim |
| pubmed-article:11895806 | lifeskim:mentions | umls-concept:C1514474 | lld:lifeskim |
| pubmed-article:11895806 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:11895806 | lifeskim:mentions | umls-concept:C1608386 | lld:lifeskim |
| pubmed-article:11895806 | lifeskim:mentions | umls-concept:C1549571 | lld:lifeskim |
| pubmed-article:11895806 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:11895806 | pubmed:dateCreated | 2002-3-15 | lld:pubmed |
| pubmed-article:11895806 | pubmed:abstractText | We investigated the prognostic value of p16(INK4a) immunocytochemistry (ICC) analysis in 126 cases of newly diagnosed childhood acute lymphoblastic leukemia (ALL). The incidence of negative p16(INK4a) ICC was 38.1% and was more frequent in T-lineage ALL. Overall survival (OS) and event-free survival (EFS) were significantly higher in patients with positive p16(INK4a) ICC than in patients with negative ICC (6 years OS, 90% versus 63%, P =.0014; 6 years EFS, 77.8% versus 55%, P =.0033). The p16(INK4a) ICC remained a significant prognostic factor within the subgroup of B-precursor ALL. Multivariate analysis showed that negative p16(INK4a) ICC was an independent prognostic factor for OS (relative risk [RR], 3.38; P =.02) and EFS (RR, 2.49; P =.018). Sequential study showed that p16(INK4a) expression remained stable during first relapse in most patients. These findings indicate that p16(INK4a) ICC is an independent factor of outcome in childhood ALL. | lld:pubmed |
| pubmed-article:11895806 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11895806 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11895806 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:11895806 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11895806 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11895806 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11895806 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:11895806 | pubmed:author | pubmed-author:FenauxPierreP | lld:pubmed |
| pubmed-article:11895806 | pubmed:author | pubmed-author:QuesnelBrunoB | lld:pubmed |
| pubmed-article:11895806 | pubmed:author | pubmed-author:DalleJean... | lld:pubmed |
| pubmed-article:11895806 | pubmed:author | pubmed-author:FournierMarti... | lld:pubmed |
| pubmed-article:11895806 | pubmed:author | pubmed-author:NelkenBrigitt... | lld:pubmed |
| pubmed-article:11895806 | pubmed:author | pubmed-author:MazingueFranç... | lld:pubmed |
| pubmed-article:11895806 | pubmed:author | pubmed-author:LaïJean-LucJL | lld:pubmed |
| pubmed-article:11895806 | pubmed:author | pubmed-author:BautersFranci... | lld:pubmed |
| pubmed-article:11895806 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11895806 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11895806 | pubmed:volume | 99 | lld:pubmed |
| pubmed-article:11895806 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11895806 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11895806 | pubmed:pagination | 2620-3 | lld:pubmed |
| pubmed-article:11895806 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:11895806 | pubmed:meshHeading | pubmed-meshheading:11895806... | lld:pubmed |
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| pubmed-article:11895806 | pubmed:meshHeading | pubmed-meshheading:11895806... | lld:pubmed |
| pubmed-article:11895806 | pubmed:meshHeading | pubmed-meshheading:11895806... | lld:pubmed |
| pubmed-article:11895806 | pubmed:meshHeading | pubmed-meshheading:11895806... | lld:pubmed |
| pubmed-article:11895806 | pubmed:meshHeading | pubmed-meshheading:11895806... | lld:pubmed |
| pubmed-article:11895806 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11895806 | pubmed:articleTitle | p16(INK4a) immunocytochemical analysis is an independent prognostic factor in childhood acute lymphoblastic leukemia. | lld:pubmed |
| pubmed-article:11895806 | pubmed:affiliation | Service des Maladies du Sang, Centre Hospitalier et Universitaire Lille, 1 place de Verdun, 59037 Lille, France. | lld:pubmed |
| pubmed-article:11895806 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11895806 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
