| pubmed-article:11891182 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11891182 | lifeskim:mentions | umls-concept:C0026848 | lld:lifeskim |
| pubmed-article:11891182 | lifeskim:mentions | umls-concept:C1519145 | lld:lifeskim |
| pubmed-article:11891182 | lifeskim:mentions | umls-concept:C0017355 | lld:lifeskim |
| pubmed-article:11891182 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:11891182 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11891182 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:11891182 | lifeskim:mentions | umls-concept:C0205359 | lld:lifeskim |
| pubmed-article:11891182 | lifeskim:mentions | umls-concept:C1611645 | lld:lifeskim |
| pubmed-article:11891182 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:11891182 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:11891182 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11891182 | pubmed:dateCreated | 2002-3-13 | lld:pubmed |
| pubmed-article:11891182 | pubmed:abstractText | We found that up-regulation of major histocompatibility complex (MHC) class I expression accompanies, but is not required for, appearance of spontaneous myopathy in SJL/J mice. In some neuromuscular diseases, MHC class I expression is markedly up-regulated in muscles, though the consequences of this up-regulation for pathology are not clear. To study MHC class I in myopathy, we compared muscles of SJL/J mice to muscles of SJL/J mice that were also MHC class I-deficient due to targeted mutation in the beta-2-microglobulin gene (SJL/J B2m (-/-) mice). SJL/J mice show spontaneous myopathy and have a mutation in the dysferlin gene, a gene which is also mutated in human limb-girdle muscular dystrophy type 2B (LGMD2B). Muscles of eight-month-old SJL/J mice had higher levels of MHC class I expression than muscles of either C57BL/6J (wild-type) or SJL/J B2m (-/-) mice. In contrast, the percentage of abnormal muscle fibers was similar in SJL/J and SJL/J B2m (-/-) muscles. Invading Mac-1(+) cells were most abundant in SJL/J B2m (-/-) muscles, moderately abundant in SJL/J muscles, and rare in C57BL/6J muscles. Thus, MHC class I was markedly up-regulated in SJL/J muscles, but this high level of MHC class I was not necessary for the appearance of myopathy. | lld:pubmed |
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| pubmed-article:11891182 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11891182 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:11891182 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11891182 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11891182 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:11891182 | pubmed:author | pubmed-author:KostekChristi... | lld:pubmed |
| pubmed-article:11891182 | pubmed:author | pubmed-author:DominovJanice... | lld:pubmed |
| pubmed-article:11891182 | pubmed:author | pubmed-author:MillerJeffrey... | lld:pubmed |
| pubmed-article:11891182 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11891182 | pubmed:volume | 160 | lld:pubmed |
| pubmed-article:11891182 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11891182 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11891182 | pubmed:pagination | 833-9 | lld:pubmed |
| pubmed-article:11891182 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11891182 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11891182 | pubmed:articleTitle | Up-regulation of MHC class I expression accompanies but is not required for spontaneous myopathy in dysferlin-deficient SJL/J mice. | lld:pubmed |
| pubmed-article:11891182 | pubmed:affiliation | Boston Biomedical Research Institute, Watertown, MA 02478, USA. | lld:pubmed |
| pubmed-article:11891182 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11891182 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11891182 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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