| pubmed-article:11886502 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11886502 | lifeskim:mentions | umls-concept:C1123023 | lld:lifeskim |
| pubmed-article:11886502 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11886502 | lifeskim:mentions | umls-concept:C1522449 | lld:lifeskim |
| pubmed-article:11886502 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:11886502 | lifeskim:mentions | umls-concept:C0025213 | lld:lifeskim |
| pubmed-article:11886502 | lifeskim:mentions | umls-concept:C0259628 | lld:lifeskim |
| pubmed-article:11886502 | lifeskim:mentions | umls-concept:C1705822 | lld:lifeskim |
| pubmed-article:11886502 | lifeskim:mentions | umls-concept:C0348011 | lld:lifeskim |
| pubmed-article:11886502 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:11886502 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:11886502 | pubmed:dateCreated | 2002-3-11 | lld:pubmed |
| pubmed-article:11886502 | pubmed:abstractText | Previous studies have shown that the protease-activated receptor 2 is involved in skin pigmentation through increased phagocytosis of melanosomes by keratinocytes. Ultraviolet irradiation is a potent stimulus for melanosome transfer. We show that protease-activated receptor 2 expression in human skin is upregulated by ultraviolet irradiation. Subjects with skin type I, II, or III were exposed to two or three minimal erythema doses of irradiation from a solar simulator. Biopsies were taken from nonexposed and irradiated skin 24 and 96 h after irradiation and protease-activated receptor 2 expression was detected using immunohistochemical staining. In nonirradiated skin, protease-activated receptor 2 expression was confined to keratinocytes in the lower one-third of the epidermis. After ultraviolet irradiation protease-activated receptor 2 expression was observed in keratinocytes in the upper two-thirds of the epidermis or the entire epidermis at both time points studied. Subjects with skin type I showed delayed upregulation of protease-activated receptor 2 expression, however, compared with subjects with skin types II and III. Irradiated cultured human keratinocytes showed upregulation in protease-activated receptor 2 expression as determined by immunofluorescence microscopy and Western blotting. Cell culture supernatants from irradiated keratinocytes also exhibited a dose-dependent increase in protease-activated receptor-2 cleavage activity. These results suggest an important role for protease-activated receptor-2 in pigmentation in vivo. Differences in protease-activated receptor 2 regulation in type I skin compared with skin types II and III suggest a potential mechanism for differences in tanning in subjects with different skin types. | lld:pubmed |
| pubmed-article:11886502 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11886502 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11886502 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11886502 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11886502 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11886502 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11886502 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11886502 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11886502 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:11886502 | pubmed:issn | 0022-202X | lld:pubmed |
| pubmed-article:11886502 | pubmed:author | pubmed-author:ScottGG | lld:pubmed |
| pubmed-article:11886502 | pubmed:author | pubmed-author:BellWW | lld:pubmed |
| pubmed-article:11886502 | pubmed:author | pubmed-author:HalTT | lld:pubmed |
| pubmed-article:11886502 | pubmed:author | pubmed-author:SeibergMM | lld:pubmed |
| pubmed-article:11886502 | pubmed:author | pubmed-author:GrizzleWW | lld:pubmed |
| pubmed-article:11886502 | pubmed:author | pubmed-author:DenkEE | lld:pubmed |
| pubmed-article:11886502 | pubmed:author | pubmed-author:PentlandAA | lld:pubmed |
| pubmed-article:11886502 | pubmed:author | pubmed-author:BabiarzLL | lld:pubmed |
| pubmed-article:11886502 | pubmed:author | pubmed-author:Rodriguez-Bur... | lld:pubmed |
| pubmed-article:11886502 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11886502 | pubmed:volume | 117 | lld:pubmed |
| pubmed-article:11886502 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11886502 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11886502 | pubmed:pagination | 1412-20 | lld:pubmed |
| pubmed-article:11886502 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:11886502 | pubmed:meshHeading | pubmed-meshheading:11886502... | lld:pubmed |
| pubmed-article:11886502 | pubmed:meshHeading | pubmed-meshheading:11886502... | lld:pubmed |
| pubmed-article:11886502 | pubmed:meshHeading | pubmed-meshheading:11886502... | lld:pubmed |
| pubmed-article:11886502 | pubmed:meshHeading | pubmed-meshheading:11886502... | lld:pubmed |
| pubmed-article:11886502 | pubmed:meshHeading | pubmed-meshheading:11886502... | lld:pubmed |
| pubmed-article:11886502 | pubmed:meshHeading | pubmed-meshheading:11886502... | lld:pubmed |
| pubmed-article:11886502 | pubmed:meshHeading | pubmed-meshheading:11886502... | lld:pubmed |
| pubmed-article:11886502 | pubmed:meshHeading | pubmed-meshheading:11886502... | lld:pubmed |
| pubmed-article:11886502 | pubmed:meshHeading | pubmed-meshheading:11886502... | lld:pubmed |
| pubmed-article:11886502 | pubmed:meshHeading | pubmed-meshheading:11886502... | lld:pubmed |
| pubmed-article:11886502 | pubmed:meshHeading | pubmed-meshheading:11886502... | lld:pubmed |
| pubmed-article:11886502 | pubmed:meshHeading | pubmed-meshheading:11886502... | lld:pubmed |
| pubmed-article:11886502 | pubmed:meshHeading | pubmed-meshheading:11886502... | lld:pubmed |
| pubmed-article:11886502 | pubmed:meshHeading | pubmed-meshheading:11886502... | lld:pubmed |
| pubmed-article:11886502 | pubmed:meshHeading | pubmed-meshheading:11886502... | lld:pubmed |
| pubmed-article:11886502 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11886502 | pubmed:articleTitle | Protease-activated receptor 2, a receptor involved in melanosome transfer, is upregulated in human skin by ultraviolet irradiation. | lld:pubmed |
| pubmed-article:11886502 | pubmed:affiliation | Department of Dermatology, University of Rochester Medical Center, School of Medicine, Rochester, New York 14642, USA. Glynis_Scott@urmc.edu | lld:pubmed |
| pubmed-article:11886502 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11886502 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11886502 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11886502 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11886502 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11886502 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11886502 | lld:pubmed |
