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pubmed-article:11886480pubmed:abstractTextTo investigate if an insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene associates with HLA-DR alleles previously found to be of prognostic interest in Scandinavian sarcoidosis patients. This may contribute to characteristics associated with these HLA-DR alleles, such as a good (DR17) or poor (DR14 or 15) prognosis. DESIGN, SETTINGS AND SUBJECTS: Polymerase chain reaction (PCR) was used for analysing an I/D polymorphism in the gene coding for ACE in 138 subjects; 65 controls and 73 sarcoidosis patients, and for HLA-DR genotyping 67 patients. Serum ACE level (S-ACE) was measured in all controls and 72 patients. Sixty-one patients were classified as chronic or nonchronic after 2 years follow-up. All patients were recruited and followed at our outpatient clinic.lld:pubmed
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pubmed-article:11886480pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:11886480pubmed:articleTitleAngiotensin-converting enzyme gene polymorphism in relation to HLA-DR in sarcoidosis.lld:pubmed
pubmed-article:11886480pubmed:affiliationDepartment of Medicine, Division of Respiratory Medicine, Karolinska Hospital, Stockholm, Sweden.lld:pubmed
pubmed-article:11886480pubmed:publicationTypeJournal Articlelld:pubmed
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