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| pubmed-article:11884415 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:11884415 | lifeskim:mentions | umls-concept:C0014239 | lld:lifeskim |
| pubmed-article:11884415 | lifeskim:mentions | umls-concept:C0018042 | lld:lifeskim |
| pubmed-article:11884415 | lifeskim:mentions | umls-concept:C0024518 | lld:lifeskim |
| pubmed-article:11884415 | lifeskim:mentions | umls-concept:C0528008 | lld:lifeskim |
| pubmed-article:11884415 | lifeskim:mentions | umls-concept:C0664943 | lld:lifeskim |
| pubmed-article:11884415 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:11884415 | lifeskim:mentions | umls-concept:C0598953 | lld:lifeskim |
| pubmed-article:11884415 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:11884415 | lifeskim:mentions | umls-concept:C1999230 | lld:lifeskim |
| pubmed-article:11884415 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:11884415 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:11884415 | pubmed:dateCreated | 2002-5-20 | lld:pubmed |
| pubmed-article:11884415 | pubmed:abstractText | Tapasin is a subunit of the transporter associated with antigen processing (TAP). It associates with the major histocompatibility complex (MHC) class I. We show that tapasin interacts with beta- and gamma-subunits of COPI coatomer. COPI retrieves membrane proteins from the Golgi network back to the endoplasmic reticulum (ER). The COPI subunit-associated tapasin also interacts with MHC class I molecules suggesting that tapasin acts as the cargo receptor for packing MHC class I molecules as cargo proteins into COPI-coated vesicles. In tapasin mutant cells, neither TAP nor MHC class I are detected in association with the COPI coatomer. Interestingly, tapasin-associated MHC class I molecules are antigenic peptide-receptive and detected in both the ER and the Golgi. Our data suggest that tapasin is required for the COPI vesicle-mediated retrograde transport of immature MHC class I molecules from the Golgi network to the ER. | lld:pubmed |
| pubmed-article:11884415 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11884415 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11884415 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11884415 | pubmed:month | May | lld:pubmed |
| pubmed-article:11884415 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:11884415 | pubmed:author | pubmed-author:WangPingP | lld:pubmed |
| pubmed-article:11884415 | pubmed:author | pubmed-author:KleijmeerMoni... | lld:pubmed |
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| pubmed-article:11884415 | pubmed:author | pubmed-author:GriffithJanic... | lld:pubmed |
| pubmed-article:11884415 | pubmed:author | pubmed-author:JevonMarcM | lld:pubmed |
| pubmed-article:11884415 | pubmed:author | pubmed-author:ChenShangwuS | lld:pubmed |
| pubmed-article:11884415 | pubmed:author | pubmed-author:AndersonPer... | lld:pubmed |
| pubmed-article:11884415 | pubmed:author | pubmed-author:SjogrenHans-O... | lld:pubmed |
| pubmed-article:11884415 | pubmed:author | pubmed-author:LiSulingS | lld:pubmed |
| pubmed-article:11884415 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11884415 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:11884415 | pubmed:volume | 277 | lld:pubmed |
| pubmed-article:11884415 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11884415 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11884415 | pubmed:pagination | 18266-71 | lld:pubmed |
| pubmed-article:11884415 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11884415 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11884415 | pubmed:articleTitle | Association of tapasin and COPI provides a mechanism for the retrograde transport of major histocompatibility complex (MHC) class I molecules from the Golgi complex to the endoplasmic reticulum. | lld:pubmed |
| pubmed-article:11884415 | pubmed:affiliation | Institution of Tumor Immunology, Lund University, Solvegatan 21, s-223 62 Lund, Sweden. | lld:pubmed |
| pubmed-article:11884415 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11884415 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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