| pubmed-article:11879578 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11879578 | lifeskim:mentions | umls-concept:C0001455 | lld:lifeskim |
| pubmed-article:11879578 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:11879578 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:11879578 | lifeskim:mentions | umls-concept:C2829390 | lld:lifeskim |
| pubmed-article:11879578 | lifeskim:mentions | umls-concept:C0086982 | lld:lifeskim |
| pubmed-article:11879578 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:11879578 | lifeskim:mentions | umls-concept:C0174878 | lld:lifeskim |
| pubmed-article:11879578 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11879578 | pubmed:dateCreated | 2002-3-6 | lld:pubmed |
| pubmed-article:11879578 | pubmed:abstractText | The serum amyloid A activating factor (SAF) was identified as a family of inducible transcription factors that is activated by many mediators of inflammation. Its activation involves a phosphorylation event, whose mechanism is not fully understood. Here, we show that cAMP treatment of several cell types, including mouse liver-derived BNL CL.2, human monocyte-derived THP-1, and a primary culture of vascular smooth muscle cells from porcine aorta, activated cellular SAF's ability to bind DNA. The protein kinase A (PKA) activity in cytoplasmic extracts of cAMP-treated cells was responsible for the potentiation of the DNA-binding activity of the cellular SAF proteins. Furthermore, treatment of nuclear extracts of untreated cells with purified PKA increased the DNA-binding activity of cellular SAF proteins, and specific inhibitors of PKA abrogated the enhanced DNA-binding ability of SAF in the cAMP-treated cells. Consistent with these findings, overexpression of the catalytic subunit of PKA markedly increased expression of the SAF-regulated promoter. These results imply a functional role for the previously detected protein-protein interaction between SAF-1 transcription factor and the catalytic subunit of PKA and further demonstrate the consequences of cAMP-mediated signaling for the expression of SAF-regulated genes. | lld:pubmed |
| pubmed-article:11879578 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11879578 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11879578 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11879578 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11879578 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11879578 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11879578 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11879578 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11879578 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11879578 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11879578 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11879578 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11879578 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11879578 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11879578 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11879578 | pubmed:issn | 1044-5498 | lld:pubmed |
| pubmed-article:11879578 | pubmed:author | pubmed-author:RayAlpanaA | lld:pubmed |
| pubmed-article:11879578 | pubmed:author | pubmed-author:RayBimal KBK | lld:pubmed |
| pubmed-article:11879578 | pubmed:author | pubmed-author:KumarDeepakD | lld:pubmed |
| pubmed-article:11879578 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11879578 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:11879578 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11879578 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11879578 | pubmed:pagination | 31-40 | lld:pubmed |
| pubmed-article:11879578 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:11879578 | pubmed:meshHeading | pubmed-meshheading:11879578... | lld:pubmed |
| pubmed-article:11879578 | pubmed:meshHeading | pubmed-meshheading:11879578... | lld:pubmed |
| pubmed-article:11879578 | pubmed:meshHeading | pubmed-meshheading:11879578... | lld:pubmed |
| pubmed-article:11879578 | pubmed:meshHeading | pubmed-meshheading:11879578... | lld:pubmed |
| pubmed-article:11879578 | pubmed:meshHeading | pubmed-meshheading:11879578... | lld:pubmed |
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| pubmed-article:11879578 | pubmed:meshHeading | pubmed-meshheading:11879578... | lld:pubmed |
| pubmed-article:11879578 | pubmed:meshHeading | pubmed-meshheading:11879578... | lld:pubmed |
| pubmed-article:11879578 | pubmed:meshHeading | pubmed-meshheading:11879578... | lld:pubmed |
| pubmed-article:11879578 | pubmed:meshHeading | pubmed-meshheading:11879578... | lld:pubmed |
| pubmed-article:11879578 | pubmed:meshHeading | pubmed-meshheading:11879578... | lld:pubmed |
| pubmed-article:11879578 | pubmed:meshHeading | pubmed-meshheading:11879578... | lld:pubmed |
| pubmed-article:11879578 | pubmed:meshHeading | pubmed-meshheading:11879578... | lld:pubmed |
| pubmed-article:11879578 | pubmed:meshHeading | pubmed-meshheading:11879578... | lld:pubmed |
| pubmed-article:11879578 | pubmed:meshHeading | pubmed-meshheading:11879578... | lld:pubmed |
| pubmed-article:11879578 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11879578 | pubmed:articleTitle | Promoter-binding activity of inflammation-responsive transcription factor SAF is regulated by cyclic AMP signaling pathway. | lld:pubmed |
| pubmed-article:11879578 | pubmed:affiliation | Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri 65211, USA. | lld:pubmed |
| pubmed-article:11879578 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11879578 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11879578 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
