| pubmed-article:11877435 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11877435 | lifeskim:mentions | umls-concept:C0178539 | lld:lifeskim |
| pubmed-article:11877435 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:11877435 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11877435 | lifeskim:mentions | umls-concept:C0907550 | lld:lifeskim |
| pubmed-article:11877435 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:11877435 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:11877435 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:11877435 | pubmed:dateCreated | 2002-5-20 | lld:pubmed |
| pubmed-article:11877435 | pubmed:abstractText | Here we report the cellular arachidonate (AA)-releasing function of group IIF secretory phospholipase A(2) (sPLA(2)-IIF), a sPLA(2) enzyme uniquely containing a longer C-terminal extension. sPLA(2)-IIF increased spontaneous and stimulus-dependent release of AA, which was supplied to downstream cyclooxygenases and 5-lipoxygenase for eicosanoid production. sPLA(2)-IIF also enhanced interleukin 1-stimulated expression of cyclooxygenase-2 and microsomal prostaglandin E synthase. AA release by sPLA(2)-IIF was facilitated by oxidative modification of cellular membranes. Cellular actions of sPLA(2)-IIF occurred independently of the heparan sulfate proteoglycan glypican, which acts as a functional adaptor for other group II subfamily sPLA(2)s. Confocal microscopy revealed the location of sPLA(2)-IIF on the plasma membrane. The unique C-terminal extension was crucial for its plasma membrane localization and optimal cellular functions. sPLA(2)-IIF expression was increased in various tissues from lipopolysaccharide-treated mice and in ears of mice with experimental atopic dermatitis. In human rheumatoid arthritic joints, sPLA(2)-IIF was detected in synovial lining cells, capillary endothelial cells, and plasma cells. These results suggest that sPLA(2)-IIF is a potent regulator of AA metabolism and participates in the inflammatory process under certain conditions. | lld:pubmed |
| pubmed-article:11877435 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11877435 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11877435 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11877435 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11877435 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11877435 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11877435 | pubmed:month | May | lld:pubmed |
| pubmed-article:11877435 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:11877435 | pubmed:author | pubmed-author:GelbMichael... | lld:pubmed |
| pubmed-article:11877435 | pubmed:author | pubmed-author:IshikawaYukio... | lld:pubmed |
| pubmed-article:11877435 | pubmed:author | pubmed-author:MurakamiMakot... | lld:pubmed |
| pubmed-article:11877435 | pubmed:author | pubmed-author:KudoIchiroI | lld:pubmed |
| pubmed-article:11877435 | pubmed:author | pubmed-author:NagaiHiroichi... | lld:pubmed |
| pubmed-article:11877435 | pubmed:author | pubmed-author:YoshiharaKumi... | lld:pubmed |
| pubmed-article:11877435 | pubmed:author | pubmed-author:ShimbaraSatok... | lld:pubmed |
| pubmed-article:11877435 | pubmed:author | pubmed-author:SawadaMasatsu... | lld:pubmed |
| pubmed-article:11877435 | pubmed:author | pubmed-author:InagakiNaokiN | lld:pubmed |
| pubmed-article:11877435 | pubmed:author | pubmed-author:LambeauGerald... | lld:pubmed |
| pubmed-article:11877435 | pubmed:author | pubmed-author:SingerAlan... | lld:pubmed |
| pubmed-article:11877435 | pubmed:author | pubmed-author:IshiharaMotok... | lld:pubmed |
| pubmed-article:11877435 | pubmed:author | pubmed-author:IshiiToshihar... | lld:pubmed |
| pubmed-article:11877435 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11877435 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:11877435 | pubmed:volume | 277 | lld:pubmed |
| pubmed-article:11877435 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11877435 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11877435 | pubmed:pagination | 19145-55 | lld:pubmed |
| pubmed-article:11877435 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:11877435 | pubmed:meshHeading | pubmed-meshheading:11877435... | lld:pubmed |
| pubmed-article:11877435 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11877435 | pubmed:articleTitle | Cellular arachidonate-releasing function and inflammation-associated expression of group IIF secretory phospholipase A2. | lld:pubmed |
| pubmed-article:11877435 | pubmed:affiliation | Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan. mako@pharm.showa-u.ac.jp | lld:pubmed |
| pubmed-article:11877435 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:64600 | entrezgene:pubmed | pubmed-article:11877435 | lld:entrezgene |
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