| pubmed-article:11877391 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11877391 | lifeskim:mentions | umls-concept:C0085103 | lld:lifeskim |
| pubmed-article:11877391 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:11877391 | lifeskim:mentions | umls-concept:C0070799 | lld:lifeskim |
| pubmed-article:11877391 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:11877391 | pubmed:dateCreated | 2002-5-6 | lld:pubmed |
| pubmed-article:11877391 | pubmed:abstractText | Phosphatidylinositol 4-phosphate 5-kinase (PIP-5kin) regulates actin cytoskeletal reorganization through its product phosphatidylinositol 4,5-bisphosphate. In the present study we demonstrate that PIP-5kin is essential for neurite remodeling, which is regulated by actin cytoskeletal reorganization in neuroblastoma N1E-115 cells. Overexpression of wild-type mouse PIP-5kin-alpha inhibits the neurite formation that is normally stimulated by serum depletion, whereas a lipid kinase-defective mutant of PIP-5kin-alpha, D266A, triggers neurite extension even in the presence of serum and blocks lysophosphatidic acid-induced neurite retraction. These results phenocopy those previously reported for the small GTPase RhoA and its effector p160 Rho-associated coiled coil-forming protein kinase (ROCK). However, the ROCK-specific inhibitor Y-27632 failed to block the inhibition by PIP-5kin-alpha of neurite extension, whereas D266A did block the neurite retraction induced by overexpression of ROCK. These results, taken together, suggest that PIP-5kin-alpha functions as a downstream effector for RhoA/ROCK to couple lysophosphatidic acid signaling to neurite retraction presumably through its product phosphatidylinositol 4,5-bisphosphate. | lld:pubmed |
| pubmed-article:11877391 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11877391 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11877391 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11877391 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11877391 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11877391 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11877391 | pubmed:month | May | lld:pubmed |
| pubmed-article:11877391 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:11877391 | pubmed:author | pubmed-author:FrohmanMichae... | lld:pubmed |
| pubmed-article:11877391 | pubmed:author | pubmed-author:WatanabeHiros... | lld:pubmed |
| pubmed-article:11877391 | pubmed:author | pubmed-author:SasakiTakehik... | lld:pubmed |
| pubmed-article:11877391 | pubmed:author | pubmed-author:KanahoYasunor... | lld:pubmed |
| pubmed-article:11877391 | pubmed:author | pubmed-author:YamazakiMasak... | lld:pubmed |
| pubmed-article:11877391 | pubmed:author | pubmed-author:MiyazakiHidey... | lld:pubmed |
| pubmed-article:11877391 | pubmed:author | pubmed-author:MaehamaTomohi... | lld:pubmed |
| pubmed-article:11877391 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11877391 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:11877391 | pubmed:volume | 277 | lld:pubmed |
| pubmed-article:11877391 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11877391 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11877391 | pubmed:pagination | 17226-30 | lld:pubmed |
| pubmed-article:11877391 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11877391 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11877391 | pubmed:articleTitle | Phosphatidylinositol 4-phosphate 5-kinase is essential for ROCK-mediated neurite remodeling. | lld:pubmed |
| pubmed-article:11877391 | pubmed:affiliation | Department of Pharmacology, the Tokyo Metropolitan Institute of Medical Science, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8613, Japan. | lld:pubmed |
| pubmed-article:11877391 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11877391 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11877391 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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