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pubmed-article:11859004pubmed:abstractTextA novel series of 2-(R)-methyl-substituted piperazines (e.g., 2) is described. They are potent M(2) selective ligands that have >100-fold selectivity versus the M(1) receptor. In the rat microdialysis assay, compound 14 showed significantly enchanced levels of acetylcholine after oral administration.lld:pubmed
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pubmed-article:11859004pubmed:articleTitleSubstituted 2-(R)-methyl piperazines as muscarinic M(2) selective ligands.lld:pubmed
pubmed-article:11859004pubmed:affiliationSchering-Plough Research Institute, Kenilworth, NJ 07033-0539, USA. joseph.kozlowski@spcorp.comlld:pubmed
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