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pubmed-article:11850860pubmed:abstractTextThis study was designed to define the prevalence of colonization with antibiotic-resistant gram-negative rectal specimens were obtained from subjects residing in 2 pediatric extended-care facilities and were processed to identify gram-negative organisms resistant to ceftazidime, gentamicin, meropenem, and piperacillin-tazobactam. Horizontal transmission was assessed by analyzing all resistant isolates by pulsed-field gel electrophoresis. Forty percent of subjects were colonized with >/=1 resistant bacillus; >60% of organisms were resistant to >/=2 of the antibiotics tested. Colonization was disproportionate among residents with a tracheostomy or other prosthesis. More than 65% of colonized subjects shared 1 organism with another resident, with cross-colonization occurring among both enteric and nonenteric species. Children residing in chronic-care facilities represent a large reservoir for resistant bacilli. Such colonization may be amenable to simple barrier infection-control procedures.lld:pubmed
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pubmed-article:11850860pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:11850860pubmed:articleTitleAntibiotic-resistant gram-negative organisms in pediatric chronic-care facilities.lld:pubmed
pubmed-article:11850860pubmed:affiliationDepartment of Pediatrics, Rainbow Babies and Children's Hospital of the University Hospitals of Cleveland, Cleveland, OH, 44106, USA. karen.lidsky@uhhs.comlld:pubmed
pubmed-article:11850860pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11850860pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed