| pubmed-article:11840327 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11840327 | lifeskim:mentions | umls-concept:C0042567 | lld:lifeskim |
| pubmed-article:11840327 | lifeskim:mentions | umls-concept:C0013935 | lld:lifeskim |
| pubmed-article:11840327 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:11840327 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:11840327 | lifeskim:mentions | umls-concept:C1336789 | lld:lifeskim |
| pubmed-article:11840327 | lifeskim:mentions | umls-concept:C0086222 | lld:lifeskim |
| pubmed-article:11840327 | lifeskim:mentions | umls-concept:C1534709 | lld:lifeskim |
| pubmed-article:11840327 | lifeskim:mentions | umls-concept:C0445223 | lld:lifeskim |
| pubmed-article:11840327 | lifeskim:mentions | umls-concept:C1552599 | lld:lifeskim |
| pubmed-article:11840327 | lifeskim:mentions | umls-concept:C1704787 | lld:lifeskim |
| pubmed-article:11840327 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:11840327 | lifeskim:mentions | umls-concept:C1998811 | lld:lifeskim |
| pubmed-article:11840327 | lifeskim:mentions | umls-concept:C1705733 | lld:lifeskim |
| pubmed-article:11840327 | pubmed:issue | 58 | lld:pubmed |
| pubmed-article:11840327 | pubmed:dateCreated | 2002-2-12 | lld:pubmed |
| pubmed-article:11840327 | pubmed:abstractText | The basic-helix-loop-helix (bHLH) proteins are a superfamily of DNA-binding transcription factors that regulate numerous biological processes in both invertebrates and vertebrates. One family of bHLH transcriptional repressors is related to the Drosophila hairy and Enhancer-of-split proteins. These repressors contain a tandem arrangement of the bHLH domain and an adjacent sequence known as the Orange domain, so we refer to these proteins as bHLH-Orange or bHLH-O proteins. Phylogenetic analysis reveals the existence of four bHLH-O subfamilies, with distinct, evolutionarily conserved features. A principal function of bHLH-O proteins is to bind to specific DNA sequences and recruit transcriptional corepressors to inhibit target gene expression. However, it is likely that bHLH-O proteins repress transcription by additional mechanisms as well. Many vertebrate bHLH-O proteins are effectors of the Notch signaling pathway, and bHLH-O proteins are involved in regulating neurogenesis, vasculogenesis, mesoderm segmentation, myogenesis, and T lymphocyte development. In this review, we discuss mechanisms of action and biological roles for the vertebrate bHLH-O proteins, as well as some of the unresolved questions about the functions and regulation of these proteins during development and in human disease. | lld:pubmed |
| pubmed-article:11840327 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11840327 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11840327 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11840327 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:11840327 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:11840327 | pubmed:author | pubmed-author:TurnerD LDL | lld:pubmed |
| pubmed-article:11840327 | pubmed:author | pubmed-author:DavisR LRL | lld:pubmed |
| pubmed-article:11840327 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11840327 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:11840327 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:11840327 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11840327 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11840327 | pubmed:pagination | 8342-57 | lld:pubmed |
| pubmed-article:11840327 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:11840327 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11840327 | pubmed:articleTitle | Vertebrate hairy and Enhancer of split related proteins: transcriptional repressors regulating cellular differentiation and embryonic patterning. | lld:pubmed |
| pubmed-article:11840327 | pubmed:affiliation | Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. | lld:pubmed |
| pubmed-article:11840327 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11840327 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:11840327 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11840327 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:11840327 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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