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pubmed-article:11824324pubmed:abstractTextPatients with unfavorable stages of lung cancer are rarely cured with local treatment modalities alone. Aim of our phase II trial was to investigate the effectivity of a multimodality treatment. Ninety-four patients with NSCLC (stage IIIA/IIIB) were treated preoperatively with chemoradiotherapy (cisplatin and etoposide, 45 Gy hyperfractionated accelerated radiotherapy). After repeat mediastinoscopy patients underwent surgery. Complete resection (R0) was achieved in 53% of all patients with NSCLC. Two patients died of sepsis preoperatively and four postoperatively (90-days lethality: 6.4%). The median survival time was 20 months for IIIA and 18 months for IIIB. Calculated survival rates at 6 years were 34% for IIIA and 17% for IIIB. This multimodality treatment demonstrates high efficacy in prognostically unfavorable NSCLC compared with historical controls.lld:pubmed
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pubmed-article:11824324pubmed:authorpubmed-author:MüllerM RMRlld:pubmed
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pubmed-article:11824324pubmed:dateRevised2007-4-24lld:pubmed
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pubmed-article:11824324pubmed:year2001lld:pubmed
pubmed-article:11824324pubmed:articleTitle[Neoadjuvant chemotherapy and chemoradiotherapy in surgically treated non-small-cell stage III bronchial carcinoma].lld:pubmed
pubmed-article:11824324pubmed:affiliationRuhrlandklinik Essen, Tüschenerweg 40, 45239 Essen.lld:pubmed
pubmed-article:11824324pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11824324pubmed:publicationTypeEnglish Abstractlld:pubmed