| pubmed-article:11823861 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11823861 | lifeskim:mentions | umls-concept:C0004364 | lld:lifeskim |
| pubmed-article:11823861 | lifeskim:mentions | umls-concept:C0439793 | lld:lifeskim |
| pubmed-article:11823861 | lifeskim:mentions | umls-concept:C1425514 | lld:lifeskim |
| pubmed-article:11823861 | lifeskim:mentions | umls-concept:C0024426 | lld:lifeskim |
| pubmed-article:11823861 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:11823861 | lifeskim:mentions | umls-concept:C0242392 | lld:lifeskim |
| pubmed-article:11823861 | pubmed:issue | 6871 | lld:pubmed |
| pubmed-article:11823861 | pubmed:dateCreated | 2002-2-1 | lld:pubmed |
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| pubmed-article:11823861 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11823861 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11823861 | pubmed:abstractText | Activation of naive CD4(+) T-helper cells results in the development of at least two distinct effector populations, Th1 and Th2 cells. Th1 cells produce cytokines (interferon (IFN)-gamma, interleukin (IL)-2, tumour-necrosis factor (TNF)-alpha and lymphotoxin) that are commonly associated with cell-mediated immune responses against intracellular pathogens, delayed-type hypersensitivity reactions, and induction of organ-specific autoimmune diseases. Th2 cells produce cytokines (IL-4, IL-10 and IL-13) that are crucial for control of extracellular helminthic infections and promote atopic and allergic diseases. Although much is known about the functions of these two subsets of T-helper cells, there are few known surface molecules that distinguish between them. We report here the identification and characterization of a transmembrane protein, Tim-3, which contains an immunoglobulin and a mucin-like domain and is expressed on differentiated Th1 cells. In vivo administration of antibody to Tim-3 enhances the clinical and pathological severity of experimental autoimmune encephalomyelitis (EAE), a Th1-dependent autoimmune disease, and increases the number and activation level of macrophages. Tim-3 may have an important role in the induction of autoimmune diseases by regulating macrophage activation and/or function. | lld:pubmed |
| pubmed-article:11823861 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11823861 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11823861 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11823861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11823861 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11823861 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11823861 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11823861 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:11823861 | pubmed:author | pubmed-author:MonneyLaurent... | lld:pubmed |
| pubmed-article:11823861 | pubmed:author | pubmed-author:SabatosCather... | lld:pubmed |
| pubmed-article:11823861 | pubmed:author | pubmed-author:GagliaJason... | lld:pubmed |
| pubmed-article:11823861 | pubmed:author | pubmed-author:RyuAkemiA | lld:pubmed |
| pubmed-article:11823861 | pubmed:author | pubmed-author:WaldnerHanspe... | lld:pubmed |
| pubmed-article:11823861 | pubmed:author | pubmed-author:ChernovaTatya... | lld:pubmed |
| pubmed-article:11823861 | pubmed:author | pubmed-author:ManningStephe... | lld:pubmed |
| pubmed-article:11823861 | pubmed:author | pubmed-author:GreenfieldEdw... | lld:pubmed |
| pubmed-article:11823861 | pubmed:author | pubmed-author:CoyleAnthony... | lld:pubmed |
| pubmed-article:11823861 | pubmed:author | pubmed-author:SobelRaymond... | lld:pubmed |
| pubmed-article:11823861 | pubmed:author | pubmed-author:FreemanGordon... | lld:pubmed |
| pubmed-article:11823861 | pubmed:author | pubmed-author:KuchrooVijay... | lld:pubmed |
| pubmed-article:11823861 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11823861 | pubmed:day | 31 | lld:pubmed |
| pubmed-article:11823861 | pubmed:volume | 415 | lld:pubmed |
| pubmed-article:11823861 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11823861 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11823861 | pubmed:pagination | 536-41 | lld:pubmed |
| pubmed-article:11823861 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11823861 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11823861 | pubmed:articleTitle | Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. | lld:pubmed |
| pubmed-article:11823861 | pubmed:affiliation | Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. | lld:pubmed |
| pubmed-article:11823861 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11823861 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11823861 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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