pubmed-article:11815491 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:11815491 | lifeskim:mentions | umls-concept:C0015663 | lld:lifeskim |
pubmed-article:11815491 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
pubmed-article:11815491 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
pubmed-article:11815491 | lifeskim:mentions | umls-concept:C2699787 | lld:lifeskim |
pubmed-article:11815491 | pubmed:dateCreated | 2002-3-7 | lld:pubmed |
pubmed-article:11815491 | pubmed:abstractText | In a cross-sectional study, we assessed beta-cell function and insulin sensitivity index (ISI) with hyperglycemic clamps (10 mmol/l) in 24 subjects with impaired fasting glycemia (IFG, fasting plasma glucose [FPG] between 6.1 and 7.0 mmol/l), 15 type 2 diabetic subjects (FPG >7.0 mmol/l), and 280 subjects with normal fasting glycemia (NFG, FPG <6.1 mmol/l). First-phase insulin release (0-10 min) was lower in IFG (geometric mean 541 pmol/l.10 min; 95% confidence interval [CI] 416-702 pmol/l.10 min) and in type 2 diabetes (geometric mean 376 pmol/l.10 min; 95% CI 247-572 pmol/l.10 min) than NFG (geometric mean 814 pmol/l.10 min; 95% CI 759-873 pmol/l.10 min) (P < 0.001). Second-phase insulin secretion (140-180 min) was also lower in IFG (geometric mean 251 pmol/l; 95% CI 198-318 pmol/l; P = 0.026) and type 2 diabetes (geometric mean 157 pmol/l; 95% CI 105-235 pmol/l; P < 0.001) than NFG (geometric mean 295 pmol/l; 95% CI 276-315 pmol/l). IFG and type 2 diabetic subjects had a lower ISI (0.15 plus minus 0.02 and 0.16 plus minus 0.02 micromol/kg fat-free mass [FFM]/min/pmol/l, respectively) than NFG (0.24 plus minus 0.01 micromol/kg FFM/min/pmol/l, P < 0.05). We found a stepwise decline in first-phase (and second-phase) secretion in NFG subjects with progressive decline in oral glucose tolerance (P < 0.05). IFG subjects with impaired glucose tolerance (IGT) had lower first-phase secretion than NFG subjects with IGT (P < 0.02), with comparable second-phase secretion and ISI. NFG and IFG subjects with a diabetic glucose tolerance (2-h glucose >11.1 mmol/l) had a lower ISI than their respective IGT counterparts (P < 0.05). We conclude that the early stages of glucose intolerance are associated with disturbances in beta-cell function, while insulin resistance is seen more markedly in later stages. | lld:pubmed |
pubmed-article:11815491 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11815491 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11815491 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11815491 | pubmed:language | eng | lld:pubmed |
pubmed-article:11815491 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11815491 | pubmed:citationSubset | AIM | lld:pubmed |
pubmed-article:11815491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11815491 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:11815491 | pubmed:month | Feb | lld:pubmed |
pubmed-article:11815491 | pubmed:issn | 0012-1797 | lld:pubmed |
pubmed-article:11815491 | pubmed:author | pubmed-author:van... | lld:pubmed |
pubmed-article:11815491 | pubmed:author | pubmed-author:GerichJohn... | lld:pubmed |
pubmed-article:11815491 | pubmed:author | pubmed-author:PimentaWalkyr... | lld:pubmed |
pubmed-article:11815491 | pubmed:author | pubmed-author:MitrakouAsimi... | lld:pubmed |
pubmed-article:11815491 | pubmed:author | pubmed-author:KorytkowskiMa... | lld:pubmed |
pubmed-article:11815491 | pubmed:author | pubmed-author:JenssenTrondT | lld:pubmed |
pubmed-article:11815491 | pubmed:author | pubmed-author:Yki-JarvinenH... | lld:pubmed |
pubmed-article:11815491 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:11815491 | pubmed:volume | 51 Suppl 1 | lld:pubmed |
pubmed-article:11815491 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:11815491 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:11815491 | pubmed:pagination | S265-70 | lld:pubmed |
pubmed-article:11815491 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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pubmed-article:11815491 | pubmed:year | 2002 | lld:pubmed |
pubmed-article:11815491 | pubmed:articleTitle | Disturbances in beta-cell function in impaired fasting glycemia. | lld:pubmed |
pubmed-article:11815491 | pubmed:affiliation | Department of Internal Medicine, University Medical Center Utrecht, Utrecht, the Netherlands. t.w.vanhaeften@azu.nl | lld:pubmed |
pubmed-article:11815491 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:11815491 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:11815491 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
pubmed-article:11815491 | pubmed:publicationType | Multicenter Study | lld:pubmed |
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