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| pubmed-article:11779461 | lifeskim:mentions | umls-concept:C1720675 | lld:lifeskim |
| pubmed-article:11779461 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:11779461 | pubmed:dateCreated | 2002-1-7 | lld:pubmed |
| pubmed-article:11779461 | pubmed:abstractText | Wnt signaling via the Frizzled (Fz) receptor controls cell polarity and movement during development, but the molecular nature of Wnt/Fz polarity signal transduction remains poorly defined. Here we report that in human cells and during Xenopus embryogenesis, Wnt/Fz signaling activates the small GTPase Rho, a key regulator of cytoskeleton architecture. Wnt/Fz activation of Rho requires the cytoplasmic protein Dishevelled (Dvl) and a novel Formin homology protein Daam1. Daam1 binds to both Dvl and Rho, and mediates Wnt-induced Dvl-Rho complex formation. Inhibition or depletion of Daam1 prevents Wnt/Fz activation of Rho and of Xenopus gastrulation, but not of beta-catenin signaling. Our study illustrates a molecular pathway from Wnt/Fz signaling to Rho activation in cell polarity signal transduction. | lld:pubmed |
| pubmed-article:11779461 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11779461 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11779461 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11779461 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:11779461 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:11779461 | pubmed:author | pubmed-author:KatoYY | lld:pubmed |
| pubmed-article:11779461 | pubmed:author | pubmed-author:HUHH | lld:pubmed |
| pubmed-article:11779461 | pubmed:author | pubmed-author:HabasRR | lld:pubmed |
| pubmed-article:11779461 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11779461 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:11779461 | pubmed:volume | 107 | lld:pubmed |
| pubmed-article:11779461 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11779461 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11779461 | pubmed:pagination | 843-54 | lld:pubmed |
| pubmed-article:11779461 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11779461 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11779461 | pubmed:articleTitle | Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. | lld:pubmed |
| pubmed-article:11779461 | pubmed:affiliation | Division of Neuroscience, Children's Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA. | lld:pubmed |
| pubmed-article:11779461 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11779461 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:11779461 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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