| pubmed-article:11756544 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11756544 | lifeskim:mentions | umls-concept:C0024501 | lld:lifeskim |
| pubmed-article:11756544 | lifeskim:mentions | umls-concept:C0025723 | lld:lifeskim |
| pubmed-article:11756544 | lifeskim:mentions | umls-concept:C1511681 | lld:lifeskim |
| pubmed-article:11756544 | lifeskim:mentions | umls-concept:C0086908 | lld:lifeskim |
| pubmed-article:11756544 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11756544 | pubmed:dateCreated | 2001-12-28 | lld:pubmed |
| pubmed-article:11756544 | pubmed:abstractText | We used mouse embryonic stem (ES) cells with systematic gene knockouts for DNA methyltransferases to delineate the roles of DNA methyltransferase 1 (Dnmt1) and Dnmt3a and -3b in maintaining methylation patterns in the mouse genome. Dnmt1 alone was able to maintain methylation of most CpG-poor regions analyzed. In contrast, both Dnmt1 and Dnmt3a and/or Dnmt3b were required for methylation of a select class of sequences which included abundant murine LINE-1 promoters. We used a novel hemimethylation assay to show that even in wild-type cells these sequences contain high levels of hemimethylated DNA, suggestive of poor maintenance methylation. We showed that Dnmt3a and/or -3b could restore methylation of these sequences to pretreatment levels following transient exposure of cells to 5-aza-CdR, whereas Dnmt1 by itself could not. We conclude that ongoing de novo methylation by Dnmt3a and/or Dnmt3b compensates for inefficient maintenance methylation by Dnmt1 of these endogenous repetitive sequences. Our results reveal a previously unrecognized degree of cooperativity among mammalian DNA methyltransferases in ES cells. | lld:pubmed |
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| pubmed-article:11756544 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11756544 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11756544 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11756544 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11756544 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:11756544 | pubmed:author | pubmed-author:GEEH KHK | lld:pubmed |
| pubmed-article:11756544 | pubmed:author | pubmed-author:LiangGangning... | lld:pubmed |
| pubmed-article:11756544 | pubmed:author | pubmed-author:ChanMatilda... | lld:pubmed |
| pubmed-article:11756544 | pubmed:author | pubmed-author:TomigaharaYos... | lld:pubmed |
| pubmed-article:11756544 | pubmed:author | pubmed-author:TsaiYvonne... | lld:pubmed |
| pubmed-article:11756544 | pubmed:author | pubmed-author:GonzalesFelic... | lld:pubmed |
| pubmed-article:11756544 | pubmed:author | pubmed-author:LairdPeter... | lld:pubmed |
| pubmed-article:11756544 | pubmed:author | pubmed-author:JonesPeter... | lld:pubmed |
| pubmed-article:11756544 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11756544 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:11756544 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11756544 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11756544 | pubmed:pagination | 480-91 | lld:pubmed |
| pubmed-article:11756544 | pubmed:dateRevised | 2010-5-21 | lld:pubmed |
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| pubmed-article:11756544 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11756544 | pubmed:articleTitle | Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements. | lld:pubmed |
| pubmed-article:11756544 | pubmed:affiliation | USC/Norris Comprehensive Cancer Center, Department of Urology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089-9181, USA. | lld:pubmed |
| pubmed-article:11756544 | pubmed:publicationType | Journal Article | lld:pubmed |
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