| pubmed-article:11751578 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11751578 | lifeskim:mentions | umls-concept:C0030657 | lld:lifeskim |
| pubmed-article:11751578 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:11751578 | lifeskim:mentions | umls-concept:C0332157 | lld:lifeskim |
| pubmed-article:11751578 | lifeskim:mentions | umls-concept:C0041221 | lld:lifeskim |
| pubmed-article:11751578 | lifeskim:mentions | umls-concept:C1414628 | lld:lifeskim |
| pubmed-article:11751578 | lifeskim:mentions | umls-concept:C0444669 | lld:lifeskim |
| pubmed-article:11751578 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:11751578 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11751578 | pubmed:dateCreated | 2002-1-18 | lld:pubmed |
| pubmed-article:11751578 | pubmed:abstractText | The macrophage infectivity potentiator protein from Trypanosoma cruzi (TcMIP) is a major virulence factor secreted by the etiological agent of Chagas' disease. It is functionally involved in host cell invasion. We have determined the three-dimensional crystal structure of TcMIP at 1.7 A resolution. The monomeric protein displays a peptidyl-prolyl cis-trans isomerase (PPIase) core, encompassing the characteristic rotamase hydrophobic active site, thus explaining the strong inhibition of TcMIP by the immunosuppressant FK506 and related drugs. In TcMIP, the twisted beta-sheet of the core is extended by an extra beta-strand, preceded by a long, exposed N-terminal alpha-helix, which might be a target recognition element. An invasion assay shows that the MIP protein from Legionella pneumophila (LpMIP), which has an equivalent N-terminal alpha-helix, can substitute for TcMIP. An additional exposed alpha-helix, this one unique to TcMIP, is located in the C-terminus of the protein. The high-resolution structure reported here opens the possibility for the design of new inhibitory drugs that might be useful for the clinical treatment of American trypanosomiasis. | lld:pubmed |
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| pubmed-article:11751578 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11751578 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11751578 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11751578 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11751578 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11751578 | pubmed:issn | 1469-221X | lld:pubmed |
| pubmed-article:11751578 | pubmed:author | pubmed-author:CollMiquelM | lld:pubmed |
| pubmed-article:11751578 | pubmed:author | pubmed-author:Gomis-RüthF... | lld:pubmed |
| pubmed-article:11751578 | pubmed:author | pubmed-author:GonzálezAnton... | lld:pubmed |
| pubmed-article:11751578 | pubmed:author | pubmed-author:PereiraPedro... | lld:pubmed |
| pubmed-article:11751578 | pubmed:author | pubmed-author:VegaM... | lld:pubmed |
| pubmed-article:11751578 | pubmed:author | pubmed-author:González-ReyE... | lld:pubmed |
| pubmed-article:11751578 | pubmed:author | pubmed-author:Fernández-Car... | lld:pubmed |
| pubmed-article:11751578 | pubmed:author | pubmed-author:Macedo-Ribeir... | lld:pubmed |
| pubmed-article:11751578 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11751578 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:11751578 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11751578 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11751578 | pubmed:pagination | 88-94 | lld:pubmed |
| pubmed-article:11751578 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11751578 | pubmed:meshHeading | pubmed-meshheading:11751578... | lld:pubmed |
| pubmed-article:11751578 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11751578 | pubmed:articleTitle | Trypanosoma cruzi macrophage infectivity potentiator has a rotamase core and a highly exposed alpha-helix. | lld:pubmed |
| pubmed-article:11751578 | pubmed:affiliation | Institut de Biología Molecular-CSIC, Jordi Girona 18-26, E-08034 Barcelona and 1Instituto de Parasitología y Biomedicina-CSIC, Ventanilla 11, E-18001 Granada, Spain. | lld:pubmed |
| pubmed-article:11751578 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11751578 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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