| pubmed-article:11728334 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11728334 | lifeskim:mentions | umls-concept:C1171348 | lld:lifeskim |
| pubmed-article:11728334 | lifeskim:mentions | umls-concept:C1155065 | lld:lifeskim |
| pubmed-article:11728334 | lifeskim:mentions | umls-concept:C0059973 | lld:lifeskim |
| pubmed-article:11728334 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:11728334 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:11728334 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:11728334 | pubmed:dateCreated | 2001-11-30 | lld:pubmed |
| pubmed-article:11728334 | pubmed:abstractText | Dynamic interactions between membrane and cytoskeleton components are crucial for T cell antigen recognition and subsequent cellular activation. We report here that the membrane-microfilament linker ezrin plays an important role in these processes. First, ezrin relocalizes to the contact area between T cells and stimulatory antigen-presenting cells (APCs), accumulating in F-actin-rich membrane protrusions at the periphery of the immunological synapse. Second, T cell receptor (TCR)-mediated intracellular signals are sufficient to induce ezrin relocalization, indicating that this protein is an effector of TCR signaling. Third, overexpression of the membrane binding domain of ezrin perturbs T cell receptor clustering in the T cell-APC contact area and inhibits the activation of nuclear factor for activated T cells (NF-AT). | lld:pubmed |
| pubmed-article:11728334 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11728334 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11728334 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11728334 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11728334 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11728334 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11728334 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11728334 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11728334 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11728334 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:11728334 | pubmed:author | pubmed-author:MichelFF | lld:pubmed |
| pubmed-article:11728334 | pubmed:author | pubmed-author:MangeatPP | lld:pubmed |
| pubmed-article:11728334 | pubmed:author | pubmed-author:Dautry-Varsat... | lld:pubmed |
| pubmed-article:11728334 | pubmed:author | pubmed-author:MartinMM | lld:pubmed |
| pubmed-article:11728334 | pubmed:author | pubmed-author:AcutoOO | lld:pubmed |
| pubmed-article:11728334 | pubmed:author | pubmed-author:ArpinMM | lld:pubmed |
| pubmed-article:11728334 | pubmed:author | pubmed-author:AlcoverAA | lld:pubmed |
| pubmed-article:11728334 | pubmed:author | pubmed-author:RoumierAA | lld:pubmed |
| pubmed-article:11728334 | pubmed:author | pubmed-author:Olivo-MarinJ... | lld:pubmed |
| pubmed-article:11728334 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11728334 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:11728334 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11728334 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11728334 | pubmed:pagination | 715-28 | lld:pubmed |
| pubmed-article:11728334 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11728334 | pubmed:meshHeading | pubmed-meshheading:11728334... | lld:pubmed |
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| pubmed-article:11728334 | pubmed:meshHeading | pubmed-meshheading:11728334... | lld:pubmed |
| pubmed-article:11728334 | pubmed:meshHeading | pubmed-meshheading:11728334... | lld:pubmed |
| pubmed-article:11728334 | pubmed:meshHeading | pubmed-meshheading:11728334... | lld:pubmed |
| pubmed-article:11728334 | pubmed:meshHeading | pubmed-meshheading:11728334... | lld:pubmed |
| pubmed-article:11728334 | pubmed:meshHeading | pubmed-meshheading:11728334... | lld:pubmed |
| pubmed-article:11728334 | pubmed:meshHeading | pubmed-meshheading:11728334... | lld:pubmed |
| pubmed-article:11728334 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11728334 | pubmed:articleTitle | The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activation. | lld:pubmed |
| pubmed-article:11728334 | pubmed:affiliation | Unité de Biologie des Interactions Cellulaires, CNRS URA 1960, Paris, France. | lld:pubmed |
| pubmed-article:11728334 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11728334 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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