| pubmed-article:11698438 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11698438 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:11698438 | lifeskim:mentions | umls-concept:C1709305 | lld:lifeskim |
| pubmed-article:11698438 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:11698438 | pubmed:dateCreated | 2001-11-7 | lld:pubmed |
| pubmed-article:11698438 | pubmed:abstractText | Naive T cells undergo homeostatic proliferation in lymphopenic mice, a process that involves TCR recognition of specific self peptide/MHC complexes. Since costimulation signals regulate the T cell response to foreign Ags, we asked whether they also regulate homeostatic expansion. We report in this study that homeostatic expansion of CD4 and CD8 T cells occurs independently of costimulation signals mediated through CD28/B7, CD40L/CD40, or 4-1BB/4-1BBL interactions. Using DO11.10 TCR transgenic T cells, we confirmed that CD28 expression was dispensable for homeostatic expansion, and showed that the presence of endogenous CD4(+)CD25(+) regulatory cells did not detectably influence homeostatic expansion. The implications of these findings with respect to regulation of T cell homeostasis and autoimmunity are discussed. | lld:pubmed |
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| pubmed-article:11698438 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11698438 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11698438 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:11698438 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11698438 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11698438 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:11698438 | pubmed:author | pubmed-author:ZelkUU | lld:pubmed |
| pubmed-article:11698438 | pubmed:author | pubmed-author:BlazarB RBR | lld:pubmed |
| pubmed-article:11698438 | pubmed:author | pubmed-author:JamesonS CSC | lld:pubmed |
| pubmed-article:11698438 | pubmed:author | pubmed-author:KhorutsAA | lld:pubmed |
| pubmed-article:11698438 | pubmed:author | pubmed-author:PrlicMM | lld:pubmed |
| pubmed-article:11698438 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11698438 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11698438 | pubmed:volume | 167 | lld:pubmed |
| pubmed-article:11698438 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11698438 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11698438 | pubmed:pagination | 5664-8 | lld:pubmed |
| pubmed-article:11698438 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:11698438 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11698438 | pubmed:articleTitle | Homeostatic expansion occurs independently of costimulatory signals. | lld:pubmed |
| pubmed-article:11698438 | pubmed:affiliation | Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA. | lld:pubmed |
| pubmed-article:11698438 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11698438 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11698438 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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