| pubmed-article:11679586 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11679586 | lifeskim:mentions | umls-concept:C0007587 | lld:lifeskim |
| pubmed-article:11679586 | lifeskim:mentions | umls-concept:C0007786 | lld:lifeskim |
| pubmed-article:11679586 | lifeskim:mentions | umls-concept:C0242184 | lld:lifeskim |
| pubmed-article:11679586 | lifeskim:mentions | umls-concept:C1418452 | lld:lifeskim |
| pubmed-article:11679586 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:11679586 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:11679586 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:11679586 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11679586 | pubmed:dateCreated | 2002-1-4 | lld:pubmed |
| pubmed-article:11679586 | pubmed:abstractText | Emerging evidence has shown that tumor suppressor p53 expression is enhanced in response to brain ischemia/hypoxia and that p53 plays a critical role in the cell death pathway in such an acute neurological insult. However the mechanism remains unclear. Recently it was reported that Peg3/Pw1, originally identified as a paternally expressed gene, plays a pivotal role in the p53-mediated cell death pathway in mouse fibroblast cell lines. In this study, we found that Peg3/Pw1 expression is enhanced in peri-ischemic neurons in rat stroke model by in situ hybridization analysis, where p53 expression was also induced by immunohistochemical analysis. Moreover, we found that p53 was co-localized with Peg3/Pw1 in brain ischemia/hypoxia by double staining analysis. In human neuroblastoma-derived SK-N-SH cells, Peg3/Pw1 mRNA expression is enhanced remarkably at 24 h post-hypoxia, when p53 protein expression was also enhanced at high levels. Subcellular localization of Peg3/Pw1 was observed in the nucleus. Adenovirus-mediated high dose p53 overexpression induced Peg3/Pw1 mRNA expression. Overexpression of Peg3/Pw1 reduced cell viability under hypoxic conditions, whereas that of the C-terminal-deleted mutant and anti-sense Peg3/Pw1 inhibited hypoxia-induced cell death. These results suggest that Peg3/Pw1 is involved in the p53-mediated cell death pathway as a downstream effector of p53 in brain ischemia/hypoxia. | lld:pubmed |
| pubmed-article:11679586 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11679586 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11679586 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11679586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11679586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11679586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11679586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11679586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11679586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11679586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11679586 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11679586 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11679586 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11679586 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:11679586 | pubmed:author | pubmed-author:SugimotoHisas... | lld:pubmed |
| pubmed-article:11679586 | pubmed:author | pubmed-author:YamaguchiAtsu... | lld:pubmed |
| pubmed-article:11679586 | pubmed:author | pubmed-author:TaniguchiMana... | lld:pubmed |
| pubmed-article:11679586 | pubmed:author | pubmed-author:HoriOsamuO | lld:pubmed |
| pubmed-article:11679586 | pubmed:author | pubmed-author:OgawaSatoshiS | lld:pubmed |
| pubmed-article:11679586 | pubmed:author | pubmed-author:TojoNobuteruN | lld:pubmed |
| pubmed-article:11679586 | pubmed:author | pubmed-author:MatsuokaNobuy... | lld:pubmed |
| pubmed-article:11679586 | pubmed:author | pubmed-author:MiyakeShin-ic... | lld:pubmed |
| pubmed-article:11679586 | pubmed:author | pubmed-author:KasaiKousukeK | lld:pubmed |
| pubmed-article:11679586 | pubmed:author | pubmed-author:TamataniMichi... | lld:pubmed |
| pubmed-article:11679586 | pubmed:author | pubmed-author:YamashitaTosh... | lld:pubmed |
| pubmed-article:11679586 | pubmed:author | pubmed-author:TohyamaMasaya... | lld:pubmed |
| pubmed-article:11679586 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11679586 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:11679586 | pubmed:volume | 277 | lld:pubmed |
| pubmed-article:11679586 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11679586 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11679586 | pubmed:pagination | 623-9 | lld:pubmed |
| pubmed-article:11679586 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11679586 | pubmed:meshHeading | pubmed-meshheading:11679586... | lld:pubmed |
| pubmed-article:11679586 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11679586 | pubmed:articleTitle | Peg3/Pw1 is involved in p53-mediated cell death pathway in brain ischemia/hypoxia. | lld:pubmed |
| pubmed-article:11679586 | pubmed:affiliation | Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. yama@anat2.med.osaka-u.ac.jp | lld:pubmed |
| pubmed-article:11679586 | pubmed:publicationType | Journal Article | lld:pubmed |
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