| pubmed-article:11602642 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11602642 | lifeskim:mentions | umls-concept:C0001675 | lld:lifeskim |
| pubmed-article:11602642 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:11602642 | lifeskim:mentions | umls-concept:C0021761 | lld:lifeskim |
| pubmed-article:11602642 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:11602642 | lifeskim:mentions | umls-concept:C0597722 | lld:lifeskim |
| pubmed-article:11602642 | lifeskim:mentions | umls-concept:C0546816 | lld:lifeskim |
| pubmed-article:11602642 | lifeskim:mentions | umls-concept:C0237477 | lld:lifeskim |
| pubmed-article:11602642 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:11602642 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:11602642 | pubmed:dateCreated | 2001-10-16 | lld:pubmed |
| pubmed-article:11602642 | pubmed:abstractText | Interleukin 7 is a crucial factor for the development of murine T and B lymphocytes. We now report that, in the absence of interleukin 7, B lymphocyte production takes place exclusively during fetal and perinatal life, ceasing after 7 wk of age. In peripheral organs, however, the pool of B lymphocytes is stable throughout adult life and consists only of cells that belong to the B1 and marginal zone (MZ) compartments. This is accompanied by a 50-fold increase in the frequency of immunoglobulin (Ig)M- and IgG-secreting cells, and the concentration of serum immunoglobulins is increased three- to fivefold. Both the MZ phenotype and the increase in serum IgM are T cell independent. These findings reveal a previously undescribed pathway of B lymphopoiesis that is active in early life and is interleukin 7 independent. This pathway generates B1 cells and a normal sized MZ B lymphocyte compartment. | lld:pubmed |
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| pubmed-article:11602642 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11602642 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11602642 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11602642 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11602642 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11602642 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:11602642 | pubmed:author | pubmed-author:CumanoAA | lld:pubmed |
| pubmed-article:11602642 | pubmed:author | pubmed-author:VieiraPP | lld:pubmed |
| pubmed-article:11602642 | pubmed:author | pubmed-author:CarvalhoT LTL | lld:pubmed |
| pubmed-article:11602642 | pubmed:author | pubmed-author:Mota-SantosTT | lld:pubmed |
| pubmed-article:11602642 | pubmed:author | pubmed-author:DemengeotJJ | lld:pubmed |
| pubmed-article:11602642 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11602642 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11602642 | pubmed:volume | 194 | lld:pubmed |
| pubmed-article:11602642 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11602642 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11602642 | pubmed:pagination | 1141-50 | lld:pubmed |
| pubmed-article:11602642 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11602642 | pubmed:year | 2001 | lld:pubmed |
