pubmed-article:11585809 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:11585809 | lifeskim:mentions | umls-concept:C0221971 | lld:lifeskim |
pubmed-article:11585809 | lifeskim:mentions | umls-concept:C0221920 | lld:lifeskim |
pubmed-article:11585809 | lifeskim:mentions | umls-concept:C0003617 | lld:lifeskim |
pubmed-article:11585809 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
pubmed-article:11585809 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
pubmed-article:11585809 | lifeskim:mentions | umls-concept:C1705630 | lld:lifeskim |
pubmed-article:11585809 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
pubmed-article:11585809 | pubmed:issue | 19 | lld:pubmed |
pubmed-article:11585809 | pubmed:dateCreated | 2001-10-4 | lld:pubmed |
pubmed-article:11585809 | pubmed:abstractText | NF-kappaB/Rel transcription factors and IkappaB kinases (IKK) are essential for inflammation and immune responses, but also for bone-morphogenesis, skin proliferation and differentiation. Determining their other functions has previously been impossible, owing to embryonic lethality of NF-kappaB/Rel or IKK-deficient animals. Using a gene targeting approach we have ubiquitously expressed an NF-kappaB super-repressor to investigate NF-kappaB functions in the adult. Mice with suppressed NF-kappaB revealed defective early morphogenesis of hair follicles, exocrine glands and teeth, identical to Eda (tabby) and Edar (downless) mutant mice. These affected epithelial appendices normally display high NF-kappaB activity, suppression of which resulted in increased apoptosis, indicating that NF-kappaB acts as a survival factor downstream of the tumor necrosis factor receptor family member EDAR. Furthermore, NF-kappaB is required for peripheral lymph node formation and macrophage function. | lld:pubmed |
pubmed-article:11585809 | pubmed:language | eng | lld:pubmed |
pubmed-article:11585809 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11585809 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:11585809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11585809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11585809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:11585809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11585809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11585809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11585809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11585809 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11585809 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:11585809 | pubmed:month | Oct | lld:pubmed |
pubmed-article:11585809 | pubmed:issn | 0950-1991 | lld:pubmed |
pubmed-article:11585809 | pubmed:author | pubmed-author:Schmidt-Ullri... | lld:pubmed |
pubmed-article:11585809 | pubmed:author | pubmed-author:BirchmeierWW | lld:pubmed |
pubmed-article:11585809 | pubmed:author | pubmed-author:ScheidereitCC | lld:pubmed |
pubmed-article:11585809 | pubmed:author | pubmed-author:AebischerTT | lld:pubmed |
pubmed-article:11585809 | pubmed:author | pubmed-author:KlemmUU | lld:pubmed |
pubmed-article:11585809 | pubmed:author | pubmed-author:HülskenJJ | lld:pubmed |
pubmed-article:11585809 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:11585809 | pubmed:volume | 128 | lld:pubmed |
pubmed-article:11585809 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:11585809 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:11585809 | pubmed:pagination | 3843-53 | lld:pubmed |
pubmed-article:11585809 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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pubmed-article:11585809 | pubmed:year | 2001 | lld:pubmed |
pubmed-article:11585809 | pubmed:articleTitle | Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices. | lld:pubmed |
pubmed-article:11585809 | pubmed:affiliation | Max-Delbrück-Center of Molecular Medicine, Robert-Rössle Strasse 10, 13092 Berlin, Germany. rschmidt@mdc-berlin.de | lld:pubmed |
pubmed-article:11585809 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:11585809 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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