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pubmed-article:11585809pubmed:abstractTextNF-kappaB/Rel transcription factors and IkappaB kinases (IKK) are essential for inflammation and immune responses, but also for bone-morphogenesis, skin proliferation and differentiation. Determining their other functions has previously been impossible, owing to embryonic lethality of NF-kappaB/Rel or IKK-deficient animals. Using a gene targeting approach we have ubiquitously expressed an NF-kappaB super-repressor to investigate NF-kappaB functions in the adult. Mice with suppressed NF-kappaB revealed defective early morphogenesis of hair follicles, exocrine glands and teeth, identical to Eda (tabby) and Edar (downless) mutant mice. These affected epithelial appendices normally display high NF-kappaB activity, suppression of which resulted in increased apoptosis, indicating that NF-kappaB acts as a survival factor downstream of the tumor necrosis factor receptor family member EDAR. Furthermore, NF-kappaB is required for peripheral lymph node formation and macrophage function.lld:pubmed
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pubmed-article:11585809pubmed:articleTitleRequirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices.lld:pubmed
pubmed-article:11585809pubmed:affiliationMax-Delbrück-Center of Molecular Medicine, Robert-Rössle Strasse 10, 13092 Berlin, Germany. rschmidt@mdc-berlin.delld:pubmed
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