| pubmed-article:11583847 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11583847 | lifeskim:mentions | umls-concept:C0085455 | lld:lifeskim |
| pubmed-article:11583847 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:11583847 | lifeskim:mentions | umls-concept:C0001390 | lld:lifeskim |
| pubmed-article:11583847 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:11583847 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:11583847 | lifeskim:mentions | umls-concept:C0062915 | lld:lifeskim |
| pubmed-article:11583847 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:11583847 | lifeskim:mentions | umls-concept:C2700116 | lld:lifeskim |
| pubmed-article:11583847 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:11583847 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:11583847 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:11583847 | lifeskim:mentions | umls-concept:C0103554 | lld:lifeskim |
| pubmed-article:11583847 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11583847 | pubmed:dateCreated | 2001-10-3 | lld:pubmed |
| pubmed-article:11583847 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11583847 | pubmed:abstractText | The antibiotic TA of Myxococcus xanthus is produced by a type-I polyketide synthase mechanism. Previous studies have indicated that TA genes are clustered within a 36-kb region. The chemical structure of TA indicates the need for several post-modification steps, which are introduced to form the final bioactive molecule. These include three C-methylations, an O-methylation and a specific hydroxylation. In this study, we describe the genetic analysis of taK, encoding a specific polyketide beta-ketoacyl:acyl carrier protein synthase, which contains an unusual beta-ketoacyl synthase and acyltransferase motifs and is likely to be involved in antibiotic TA post-modification. Functional analysis of this beta-ketoacyl:acyl carrier protein synthase by specific gene disruption suggests that it is essential for the production of an active TA molecule. | lld:pubmed |
| pubmed-article:11583847 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11583847 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11583847 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11583847 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11583847 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11583847 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11583847 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11583847 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11583847 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11583847 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11583847 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11583847 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11583847 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11583847 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:11583847 | pubmed:issn | 0378-1097 | lld:pubmed |
| pubmed-article:11583847 | pubmed:author | pubmed-author:RosenbergEE | lld:pubmed |
| pubmed-article:11583847 | pubmed:author | pubmed-author:RonE ZEZ | lld:pubmed |
| pubmed-article:11583847 | pubmed:author | pubmed-author:OrrEE | lld:pubmed |
| pubmed-article:11583847 | pubmed:author | pubmed-author:PaitanYY | lld:pubmed |
| pubmed-article:11583847 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11583847 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:11583847 | pubmed:volume | 203 | lld:pubmed |
| pubmed-article:11583847 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11583847 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11583847 | pubmed:pagination | 191-7 | lld:pubmed |
| pubmed-article:11583847 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11583847 | pubmed:meshHeading | pubmed-meshheading:11583847... | lld:pubmed |
| pubmed-article:11583847 | pubmed:meshHeading | pubmed-meshheading:11583847... | lld:pubmed |
| pubmed-article:11583847 | pubmed:meshHeading | pubmed-meshheading:11583847... | lld:pubmed |
| pubmed-article:11583847 | pubmed:meshHeading | pubmed-meshheading:11583847... | lld:pubmed |
| pubmed-article:11583847 | pubmed:meshHeading | pubmed-meshheading:11583847... | lld:pubmed |
| pubmed-article:11583847 | pubmed:meshHeading | pubmed-meshheading:11583847... | lld:pubmed |
| pubmed-article:11583847 | pubmed:meshHeading | pubmed-meshheading:11583847... | lld:pubmed |
| pubmed-article:11583847 | pubmed:meshHeading | pubmed-meshheading:11583847... | lld:pubmed |
| pubmed-article:11583847 | pubmed:meshHeading | pubmed-meshheading:11583847... | lld:pubmed |
| pubmed-article:11583847 | pubmed:meshHeading | pubmed-meshheading:11583847... | lld:pubmed |
| pubmed-article:11583847 | pubmed:meshHeading | pubmed-meshheading:11583847... | lld:pubmed |
| pubmed-article:11583847 | pubmed:meshHeading | pubmed-meshheading:11583847... | lld:pubmed |
| pubmed-article:11583847 | pubmed:meshHeading | pubmed-meshheading:11583847... | lld:pubmed |
| pubmed-article:11583847 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11583847 | pubmed:articleTitle | An unusual beta-ketoacyl:acyl carrier protein synthase and acyltransferase motifs in TaK, a putative protein required for biosynthesis of the antibiotic TA in Myxococcus xanthus. | lld:pubmed |
| pubmed-article:11583847 | pubmed:affiliation | Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Israel. | lld:pubmed |
| pubmed-article:11583847 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11583847 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
