| pubmed-article:11583628 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11583628 | lifeskim:mentions | umls-concept:C0076930 | lld:lifeskim |
| pubmed-article:11583628 | lifeskim:mentions | umls-concept:C1514758 | lld:lifeskim |
| pubmed-article:11583628 | lifeskim:mentions | umls-concept:C1522240 | lld:lifeskim |
| pubmed-article:11583628 | lifeskim:mentions | umls-concept:C1707719 | lld:lifeskim |
| pubmed-article:11583628 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11583628 | pubmed:dateCreated | 2001-10-3 | lld:pubmed |
| pubmed-article:11583628 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11583628 | pubmed:abstractText | The type I TGF beta receptor (T beta R-I) is activated by phosphorylation of the GS region, a conserved juxtamembrane segment located just N-terminal to the kinase domain. We have studied the molecular mechanism of receptor activation using a homogeneously tetraphosphorylated form of T beta R-I, prepared using protein semisynthesis. Phosphorylation of the GS region dramatically enhances the specificity of T beta R-I for the critical C-terminal serines of Smad2. In addition, tetraphosphorylated T beta R-I is bound specifically by Smad2 in a phosphorylation-dependent manner and is no longer recognized by the inhibitory protein FKBP12. Thus, phosphorylation activates T beta R-I by switching the GS region from a binding site for an inhibitor into a binding surface for substrate. Our observations suggest that phosphoserine/phosphothreonine-dependent localization is a key feature of the T beta R-I/Smad activation process. | lld:pubmed |
| pubmed-article:11583628 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11583628 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11583628 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11583628 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11583628 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11583628 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11583628 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11583628 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11583628 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11583628 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11583628 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11583628 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11583628 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11583628 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11583628 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11583628 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11583628 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11583628 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11583628 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11583628 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11583628 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:11583628 | pubmed:issn | 1097-2765 | lld:pubmed |
| pubmed-article:11583628 | pubmed:author | pubmed-author:MassaguéJJ | lld:pubmed |
| pubmed-article:11583628 | pubmed:author | pubmed-author:YUMM | lld:pubmed |
| pubmed-article:11583628 | pubmed:author | pubmed-author:KuriyanJJ | lld:pubmed |
| pubmed-article:11583628 | pubmed:author | pubmed-author:ChenY GYG | lld:pubmed |
| pubmed-article:11583628 | pubmed:author | pubmed-author:NealE SES | lld:pubmed |
| pubmed-article:11583628 | pubmed:author | pubmed-author:HuseMM | lld:pubmed |
| pubmed-article:11583628 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11583628 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:11583628 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11583628 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11583628 | pubmed:pagination | 671-82 | lld:pubmed |
| pubmed-article:11583628 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:11583628 | pubmed:meshHeading | pubmed-meshheading:11583628... | lld:pubmed |
| pubmed-article:11583628 | pubmed:meshHeading | pubmed-meshheading:11583628... | lld:pubmed |
| pubmed-article:11583628 | pubmed:meshHeading | pubmed-meshheading:11583628... | lld:pubmed |
| pubmed-article:11583628 | pubmed:meshHeading | pubmed-meshheading:11583628... | lld:pubmed |
| pubmed-article:11583628 | pubmed:meshHeading | pubmed-meshheading:11583628... | lld:pubmed |
| pubmed-article:11583628 | pubmed:meshHeading | pubmed-meshheading:11583628... | lld:pubmed |
| pubmed-article:11583628 | pubmed:meshHeading | pubmed-meshheading:11583628... | lld:pubmed |
| pubmed-article:11583628 | pubmed:meshHeading | pubmed-meshheading:11583628... | lld:pubmed |
| pubmed-article:11583628 | pubmed:meshHeading | pubmed-meshheading:11583628... | lld:pubmed |
| pubmed-article:11583628 | pubmed:meshHeading | pubmed-meshheading:11583628... | lld:pubmed |
| pubmed-article:11583628 | pubmed:meshHeading | pubmed-meshheading:11583628... | lld:pubmed |
| pubmed-article:11583628 | pubmed:meshHeading | pubmed-meshheading:11583628... | lld:pubmed |
| pubmed-article:11583628 | pubmed:meshHeading | pubmed-meshheading:11583628... | lld:pubmed |
| pubmed-article:11583628 | pubmed:meshHeading | pubmed-meshheading:11583628... | lld:pubmed |
| pubmed-article:11583628 | pubmed:meshHeading | pubmed-meshheading:11583628... | lld:pubmed |
| pubmed-article:11583628 | pubmed:meshHeading | pubmed-meshheading:11583628... | lld:pubmed |
| pubmed-article:11583628 | pubmed:meshHeading | pubmed-meshheading:11583628... | lld:pubmed |
| pubmed-article:11583628 | pubmed:meshHeading | pubmed-meshheading:11583628... | lld:pubmed |
| pubmed-article:11583628 | pubmed:meshHeading | pubmed-meshheading:11583628... | lld:pubmed |
| pubmed-article:11583628 | pubmed:meshHeading | pubmed-meshheading:11583628... | lld:pubmed |
| pubmed-article:11583628 | pubmed:meshHeading | pubmed-meshheading:11583628... | lld:pubmed |
| pubmed-article:11583628 | pubmed:meshHeading | pubmed-meshheading:11583628... | lld:pubmed |
| pubmed-article:11583628 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11583628 | pubmed:articleTitle | The TGF beta receptor activation process: an inhibitor- to substrate-binding switch. | lld:pubmed |
| pubmed-article:11583628 | pubmed:affiliation | Laboratory of Molecular Biophysics, Rockefeller University, New York, NY 10021, USA. | lld:pubmed |
| pubmed-article:11583628 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11583628 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11583628 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:11583628 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:7046 | entrezgene:pubmed | pubmed-article:11583628 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11583628 | lld:pubmed |
