| pubmed-article:11581317 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11581317 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:11581317 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:11581317 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:11581317 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:11581317 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:11581317 | lifeskim:mentions | umls-concept:C0232901 | lld:lifeskim |
| pubmed-article:11581317 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:11581317 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:11581317 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:11581317 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:11581317 | pubmed:dateCreated | 2001-10-2 | lld:pubmed |
| pubmed-article:11581317 | pubmed:abstractText | It has been proposed that two different antigen-experienced T cell subsets may be distinguishable by their preferential ability to home to lymphoid organs (central memory cells) or nonlymphoid tissues (effector memory/effector cells). We have shown recently that murine antigen-primed CD8(+) T cells cultured in interleukin (IL)-15 (CD8(IL-15)) resemble central memory cells in phenotype and function. In contrast, primed CD8(+) T cells cultured in IL-2 (CD8(IL-2)) become cytotoxic effector cells. Here, the migratory behavior of these two subsets was investigated. Naive, CD8(IL-15) cells and, to a lesser degree, CD8(IL-2) cells localized to T cell areas in the spleen, but only naive and CD8(IL-15) cells homed to lymph nodes (LNs) and Peyer's patches. Intravital microscopy of peripheral LNs revealed that CD8(IL-15) cells, but not CD8(IL-2) cells, rolled and arrested in high endothelial venules (HEVs). Migration of CD8(IL-15) cells to LNs depended on L-selectin and required chemokines that bind CC chemokine receptor (CCR)7. Both antigen-experienced populations, but not naive T cells, responded to inflammatory chemokines and accumulated at sites of inflammation. However, CD8(IL-2) cells were 12 times more efficient in migrating to inflamed peritoneum than CD8(IL-15) cells. Furthermore, CD8(IL-15) cells proliferated rapidly upon reencounter with antigen at sites of inflammation. Thus, central memory-like CD8(IL-15) cells home avidly to lymphoid organs and moderately to sites of inflammation, where they mediate rapid recall responses, whereas CD8(IL-2) effector T cells accumulate in inflamed tissues, but are excluded from most lymphoid organs. | lld:pubmed |
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| pubmed-article:11581317 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11581317 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11581317 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11581317 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11581317 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11581317 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11581317 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11581317 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:11581317 | pubmed:author | pubmed-author:CrowleyM AMA | lld:pubmed |
| pubmed-article:11581317 | pubmed:author | pubmed-author:von... | lld:pubmed |
| pubmed-article:11581317 | pubmed:author | pubmed-author:ManjunathNN | lld:pubmed |
| pubmed-article:11581317 | pubmed:author | pubmed-author:WeningerWW | lld:pubmed |
| pubmed-article:11581317 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11581317 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11581317 | pubmed:volume | 194 | lld:pubmed |
| pubmed-article:11581317 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11581317 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11581317 | pubmed:pagination | 953-66 | lld:pubmed |
| pubmed-article:11581317 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:11581317 | pubmed:meshHeading | pubmed-meshheading:11581317... | lld:pubmed |
| pubmed-article:11581317 | pubmed:meshHeading | pubmed-meshheading:11581317... | lld:pubmed |
| pubmed-article:11581317 | pubmed:meshHeading | pubmed-meshheading:11581317... | lld:pubmed |
