| pubmed-article:11577989 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11577989 | lifeskim:mentions | umls-concept:C0431085 | lld:lifeskim |
| pubmed-article:11577989 | lifeskim:mentions | umls-concept:C0243045 | lld:lifeskim |
| pubmed-article:11577989 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:11577989 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:11577989 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:11577989 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:11577989 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:11577989 | pubmed:dateCreated | 2001-10-1 | lld:pubmed |
| pubmed-article:11577989 | pubmed:abstractText | Activation of the p53 tumour suppressor protein by distinct forms of stress leads to inhibition of cellular proliferation by inducing cell cycle arrest or apoptosis. The cyclin-dependent kinase inhibitor roscovitine has been shown to induce nuclear accumulation of wild-type p53 in human untransformed and tumour-derived cells. We analyzed the response of different human tumour cell lines to roscovitine treatment with respect to their p53 status. Striking induction of wild-type p53 protein and dramatic enhancement of p53-dependent transcription, coinciding with p21WAF1 induction, was observed in wildtype, but not mutant, p53-bearing tumour cells after treatment with roscovitine. The transcriptional activity of p53 was substantially higher in roscovitine-treated cells than in cells irradiated with ultraviolet C or ionizing radiation, even though all these agents induced a similar amount of p53 accumulation. These results highlight the therapeutic potential of roscovitine as an anticancer drug, especially in tumours retaining a functional wild-type p53 pathway. | lld:pubmed |
| pubmed-article:11577989 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11577989 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11577989 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11577989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11577989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11577989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11577989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11577989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11577989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11577989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11577989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11577989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11577989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11577989 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11577989 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11577989 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:11577989 | pubmed:issn | 1420-682X | lld:pubmed |
| pubmed-article:11577989 | pubmed:author | pubmed-author:StrnadMM | lld:pubmed |
| pubmed-article:11577989 | pubmed:author | pubmed-author:VojtesekBB | lld:pubmed |
| pubmed-article:11577989 | pubmed:author | pubmed-author:TrbusekMM | lld:pubmed |
| pubmed-article:11577989 | pubmed:author | pubmed-author:KotalaVV | lld:pubmed |
| pubmed-article:11577989 | pubmed:author | pubmed-author:HorkyMM | lld:pubmed |
| pubmed-article:11577989 | pubmed:author | pubmed-author:UldrijanSS | lld:pubmed |
| pubmed-article:11577989 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11577989 | pubmed:volume | 58 | lld:pubmed |
| pubmed-article:11577989 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11577989 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11577989 | pubmed:pagination | 1333-9 | lld:pubmed |
| pubmed-article:11577989 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11577989 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11577989 | pubmed:articleTitle | Potent induction of wild-type p53-dependent transcription in tumour cells by a synthetic inhibitor of cyclin-dependent kinases. | lld:pubmed |
| pubmed-article:11577989 | pubmed:affiliation | Department of Experimental Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic. | lld:pubmed |
| pubmed-article:11577989 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11577989 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11577989 | lld:pubmed |
