Linked Life Data

11566802

Source:http://linkedlifedata.com/resource/pubmed/id/11566802

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:11566802rdf:typepubmed:Citationlld:pubmed
pubmed-article:11566802lifeskim:mentionsumls-concept:C0237401lld:lifeskim
pubmed-article:11566802lifeskim:mentionsumls-concept:C1179435lld:lifeskim
pubmed-article:11566802lifeskim:mentionsumls-concept:C0392747lld:lifeskim
pubmed-article:11566802lifeskim:mentionsumls-concept:C1705248lld:lifeskim
pubmed-article:11566802lifeskim:mentionsumls-concept:C1548799lld:lifeskim
pubmed-article:11566802lifeskim:mentionsumls-concept:C1524073lld:lifeskim
pubmed-article:11566802lifeskim:mentionsumls-concept:C0449432lld:lifeskim
pubmed-article:11566802pubmed:issue4lld:pubmed
pubmed-article:11566802pubmed:dateCreated2001-9-21lld:pubmed
pubmed-article:11566802pubmed:abstractTextThis communication introduces a simple method to determine the pKs of microscopic ionizations from complex titration curves. We used this approach to study the alkaline transition (pH-dependent ligand exchange) of mitochondrial cytochrome c. The linearization of titration curves permitted resolution of two to three limiting microscopic ionizations. By combining these data with studies of the temperature dependence of ligand-exchange equilibria, we found evidence that the alkaline transition comprises two chemically distinct processes: the deprotonation of the alternative ligands and the break of the iron-methionine ligation bond. We also noted that, in the horse and untrimethylated S. cerevisiae iso-1 cytochromes c, the permissible deprotonation of the epsilon-amino group of Lys(72) allows formation of an alkaline isomer at lower pH, with lesser stability, which leads to hysteresis in the titration curves. The linearization of the titration curves for different cytochromes c thus brings insight on the microscopic contributions to conformational stability.lld:pubmed
pubmed-article:11566802pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:languageenglld:pubmed
pubmed-article:11566802pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:citationSubsetIMlld:pubmed
pubmed-article:11566802pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11566802pubmed:statusMEDLINElld:pubmed
pubmed-article:11566802pubmed:monthOctlld:pubmed
pubmed-article:11566802pubmed:issn0006-3495lld:pubmed
pubmed-article:11566802pubmed:authorpubmed-author:WallaceC JCJlld:pubmed
pubmed-article:11566802pubmed:authorpubmed-author:GuillemetteJ...lld:pubmed
pubmed-article:11566802pubmed:authorpubmed-author:BlouinCClld:pubmed
pubmed-article:11566802pubmed:issnTypePrintlld:pubmed
pubmed-article:11566802pubmed:volume81lld:pubmed
pubmed-article:11566802pubmed:ownerNLMlld:pubmed
pubmed-article:11566802pubmed:authorsCompleteYlld:pubmed
pubmed-article:11566802pubmed:pagination2331-8lld:pubmed
pubmed-article:11566802pubmed:dateRevised2009-11-18lld:pubmed
pubmed-article:11566802pubmed:meshHeadingpubmed-meshheading:11566802...lld:pubmed
pubmed-article:11566802pubmed:meshHeadingpubmed-meshheading:11566802...lld:pubmed
pubmed-article:11566802pubmed:meshHeadingpubmed-meshheading:11566802...lld:pubmed
pubmed-article:11566802pubmed:meshHeadingpubmed-meshheading:11566802...lld:pubmed
pubmed-article:11566802pubmed:meshHeadingpubmed-meshheading:11566802...lld:pubmed
pubmed-article:11566802pubmed:meshHeadingpubmed-meshheading:11566802...lld:pubmed
pubmed-article:11566802pubmed:meshHeadingpubmed-meshheading:11566802...lld:pubmed
pubmed-article:11566802pubmed:meshHeadingpubmed-meshheading:11566802...lld:pubmed
pubmed-article:11566802pubmed:meshHeadingpubmed-meshheading:11566802...lld:pubmed
pubmed-article:11566802pubmed:meshHeadingpubmed-meshheading:11566802...lld:pubmed
pubmed-article:11566802pubmed:meshHeadingpubmed-meshheading:11566802...lld:pubmed
pubmed-article:11566802pubmed:meshHeadingpubmed-meshheading:11566802...lld:pubmed
pubmed-article:11566802pubmed:meshHeadingpubmed-meshheading:11566802...lld:pubmed
pubmed-article:11566802pubmed:meshHeadingpubmed-meshheading:11566802...lld:pubmed
pubmed-article:11566802pubmed:meshHeadingpubmed-meshheading:11566802...lld:pubmed
pubmed-article:11566802pubmed:meshHeadingpubmed-meshheading:11566802...lld:pubmed
pubmed-article:11566802pubmed:meshHeadingpubmed-meshheading:11566802...lld:pubmed
pubmed-article:11566802pubmed:meshHeadingpubmed-meshheading:11566802...lld:pubmed
pubmed-article:11566802pubmed:year2001lld:pubmed
pubmed-article:11566802pubmed:articleTitleResolving the individual components of a pH-induced conformational change.lld:pubmed
pubmed-article:11566802pubmed:affiliationDepartment of Biochemistry and Molecular Biology, Dalhousie University, Nova Scotia B3H 4H7, Canada.lld:pubmed
pubmed-article:11566802pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11566802pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11566802lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11566802lld:pubmed