| pubmed-article:11562498 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11562498 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:11562498 | lifeskim:mentions | umls-concept:C0019699 | lld:lifeskim |
| pubmed-article:11562498 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:11562498 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:11562498 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:11562498 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:11562498 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:11562498 | pubmed:dateCreated | 2001-9-26 | lld:pubmed |
| pubmed-article:11562498 | pubmed:abstractText | Stimulation with antibodies to CD3 and CD28 coimmobilized on beads can be used to significantly expand T cells ex vivo. With CD4 T cells from HIV-infected patients, this expansion usually is accompanied by complete suppression of viral replication, presumed to be caused by down-regulation of the viral coreceptor CCR5 and up-regulation of CCR5 ligands. Here we show that this suppression occurs in total CD4 T cells acutely infected with R5 HIV, but not in purified CD62L(-) memory CD4 T cells. The lack of complete suppression in these memory cells, typically comprising 10-40% of total CD4 T cells, occurs despite high levels of CCR5 ligand secretion and down-regulation of CCR5. Significantly, adding back naive or CD62L(+) memory CD4 T cells inhibits the viral replication in the CD62L(-) cells, with the naive cells capable of completely repressing the virus. Although this inhibition was previously thought to be specific to bead-bound anti-CD3/CD28 stimulation, we show that the same suppression is obtained with sufficiently strong anti-CD3/B7.1 stimulation. Our results show that inhibitory mechanisms, expressed predominantly by strongly stimulated naive CD4 T cells and mediated independently of CCR5-binding chemokines, play a role in the inhibition of R5 HIV replication in CD4 T cells upon CD28 costimulation. | lld:pubmed |
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| pubmed-article:11562498 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11562498 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11562498 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11562498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11562498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11562498 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11562498 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:11562498 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:11562498 | pubmed:author | pubmed-author:HerzenbergL... | lld:pubmed |
| pubmed-article:11562498 | pubmed:author | pubmed-author:RoedererMM | lld:pubmed |
| pubmed-article:11562498 | pubmed:author | pubmed-author:MengozziMM | lld:pubmed |
| pubmed-article:11562498 | pubmed:author | pubmed-author:De RosaS CSC | lld:pubmed |
| pubmed-article:11562498 | pubmed:author | pubmed-author:MalipatlollaM... | lld:pubmed |
| pubmed-article:11562498 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11562498 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:11562498 | pubmed:volume | 98 | lld:pubmed |
| pubmed-article:11562498 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11562498 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11562498 | pubmed:pagination | 11644-9 | lld:pubmed |
| pubmed-article:11562498 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11562498 | pubmed:meshHeading | pubmed-meshheading:11562498... | lld:pubmed |
| pubmed-article:11562498 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11562498 | pubmed:articleTitle | Naive CD4 T cells inhibit CD28-costimulated R5 HIV replication in memory CD4 T cells. | lld:pubmed |
| pubmed-article:11562498 | pubmed:affiliation | Department of Genetics, Stanford University, Stanford, CA 94305-5318, USA. | lld:pubmed |
| pubmed-article:11562498 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11562498 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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