pubmed-article:11557039 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:11557039 | lifeskim:mentions | umls-concept:C0108555 | lld:lifeskim |
pubmed-article:11557039 | lifeskim:mentions | umls-concept:C1825546 | lld:lifeskim |
pubmed-article:11557039 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
pubmed-article:11557039 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
pubmed-article:11557039 | lifeskim:mentions | umls-concept:C1145667 | lld:lifeskim |
pubmed-article:11557039 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
pubmed-article:11557039 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
pubmed-article:11557039 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
pubmed-article:11557039 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:11557039 | pubmed:dateCreated | 2001-9-14 | lld:pubmed |
pubmed-article:11557039 | pubmed:abstractText | Surface plasmon resonance analysis shows that the carboxy-terminal domain of Grp94 (Grp94-CT, residues 518-803) physically interacts with the catalytic subunit of protein kinase CK2 (CK2 alpha) under non-stressed conditions. A K(D) of 4 x 10(-7) was determined for this binding. Heparin competed with Grp94-CT for binding to CK2 alpha. CK2 beta also inhibited the binding of Grp94-CT to CK2 alpha, and CK2 holoenzyme reconstituted in vitro was unable to bind Grp94-CT. The use of CK2 alpha mutants made it possible to map the Grp94-CT binding site to the four lysine stretch (residues 74-77) present in helix C of CK2 alpha. Grp94-CT stimulated the activity of CK2 alpha wild-type but was ineffective on the CK2 alpha K74-77A mutant. | lld:pubmed |
pubmed-article:11557039 | pubmed:language | eng | lld:pubmed |
pubmed-article:11557039 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11557039 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:11557039 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:11557039 | pubmed:month | Sep | lld:pubmed |
pubmed-article:11557039 | pubmed:issn | 0014-5793 | lld:pubmed |
pubmed-article:11557039 | pubmed:author | pubmed-author:ItarteEE | lld:pubmed |
pubmed-article:11557039 | pubmed:author | pubmed-author:PinnaL ALA | lld:pubmed |
pubmed-article:11557039 | pubmed:author | pubmed-author:MeitusM LML | lld:pubmed |
pubmed-article:11557039 | pubmed:author | pubmed-author:RuzzeneMM | lld:pubmed |
pubmed-article:11557039 | pubmed:author | pubmed-author:SarnoSS | lld:pubmed |
pubmed-article:11557039 | pubmed:author | pubmed-author:MiróFF | lld:pubmed |
pubmed-article:11557039 | pubmed:author | pubmed-author:PlanaMM | lld:pubmed |
pubmed-article:11557039 | pubmed:author | pubmed-author:RohelDD | lld:pubmed |
pubmed-article:11557039 | pubmed:author | pubmed-author:LlorensFF | lld:pubmed |
pubmed-article:11557039 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:11557039 | pubmed:day | 7 | lld:pubmed |
pubmed-article:11557039 | pubmed:volume | 505 | lld:pubmed |
pubmed-article:11557039 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:11557039 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:11557039 | pubmed:pagination | 42-6 | lld:pubmed |
pubmed-article:11557039 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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pubmed-article:11557039 | pubmed:year | 2001 | lld:pubmed |
pubmed-article:11557039 | pubmed:articleTitle | The carboxy-terminal domain of Grp94 binds to protein kinase CK2 alpha but not to CK2 holoenzyme. | lld:pubmed |
pubmed-article:11557039 | pubmed:affiliation | Department de Bioquímica i Biologia Molcular, Facultat de Ciències, Universitat Autònoma de Barcelona, Spain. | lld:pubmed |
pubmed-article:11557039 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:11557039 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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