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pubmed-article:11553484pubmed:abstractTextMixed pyrimidine-purine peptide nucleic acids (PNAs) composed of thymines and guanines are shown to form a PNA(2)-DNA triplex with Watson-Crick complementary adenine-cytosine oligonucleotides and to bind complementary adenine-cytosine targets in double stranded DNA by helix invasion. These results for the first time demonstrate binding of an unmodified PNA oligomer to a mixed pyrimidine-purine target in double stranded DNA and illustrate a novel binding mode of PNA.lld:pubmed
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pubmed-article:11553484pubmed:articleTitleStrand displacement recognition of mixed adenine-cytosine sequences in double stranded DNA by thymine-guanine PNA (peptide nucleic acid).lld:pubmed
pubmed-article:11553484pubmed:affiliationCenter for Biomolecular Recognition, Department for Biochemistry and Genetics, Biochemistry Laboratory B, The Panum Institute, Blegdamsvej 3c, DK-2200N Copenhagen, Denmark. pen@imbg.ku.dklld:pubmed
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