| pubmed-article:11549597 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11549597 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11549597 | lifeskim:mentions | umls-concept:C0678222 | lld:lifeskim |
| pubmed-article:11549597 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:11549597 | lifeskim:mentions | umls-concept:C0027627 | lld:lifeskim |
| pubmed-article:11549597 | lifeskim:mentions | umls-concept:C1518174 | lld:lifeskim |
| pubmed-article:11549597 | lifeskim:mentions | umls-concept:C0245382 | lld:lifeskim |
| pubmed-article:11549597 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:11549597 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11549597 | pubmed:dateCreated | 2001-9-10 | lld:pubmed |
| pubmed-article:11549597 | pubmed:abstractText | Galectin-3 is a beta-galactoside-binding protein which regulates many biological processes including cell adhesion, migration, cell growth, tumor progression, metastasis, and apoptosis. Although the exact function of galectin-3 in cancer development is unclear, galectin-3 expression is associated with neoplastic progression and metastatic potential. Since studies have suggested that tumor cell survival in microcirculation determines the metastatic outcome, we examined the effect of galectin-3 overexpression in human breast carcinoma cell survival using the liver ischemia/reperfusion metastasis model. While the majority of control cells died by hepatic ischemia/reoxygenation, nearly all of galectin-3 overexpressing cells survived. We showed that galectin-3 inhibits nitrogen free radical-mediated apoptosis, one of the major death pathways induced during hepatic ischemia/reperfusion. Galectin-3 inhibition of apoptosis involved protection of mitochondrial integrity, inhibition of cytochrome c release and caspase activation. Taking these results together with the previous observation that galectin-3 inhibits apoptosis induced by loss of cell adhesion, we propose that galectin-3 is a critical determinant for anchorage-independent and free radical-resistant cell survival during metastasis. | lld:pubmed |
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| pubmed-article:11549597 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11549597 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11549597 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:11549597 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11549597 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:11549597 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:11549597 | pubmed:author | pubmed-author:RauLL | lld:pubmed |
| pubmed-article:11549597 | pubmed:author | pubmed-author:JessupJ MJM | lld:pubmed |
| pubmed-article:11549597 | pubmed:author | pubmed-author:LamK BKB | lld:pubmed |
| pubmed-article:11549597 | pubmed:author | pubmed-author:LeeY JYJ | lld:pubmed |
| pubmed-article:11549597 | pubmed:author | pubmed-author:MoonB KBK | lld:pubmed |
| pubmed-article:11549597 | pubmed:author | pubmed-author:BattlePP | lld:pubmed |
| pubmed-article:11549597 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11549597 | pubmed:volume | 159 | lld:pubmed |
| pubmed-article:11549597 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11549597 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11549597 | pubmed:pagination | 1055-60 | lld:pubmed |
| pubmed-article:11549597 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11549597 | pubmed:meshHeading | pubmed-meshheading:11549597... | lld:pubmed |
| pubmed-article:11549597 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11549597 | pubmed:articleTitle | Galectin-3 protects human breast carcinoma cells against nitric oxide-induced apoptosis: implication of galectin-3 function during metastasis. | lld:pubmed |
| pubmed-article:11549597 | pubmed:affiliation | Department of Anesthesiology, Ajou University School of Medicine, Suwon, Korea. | lld:pubmed |
| pubmed-article:11549597 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11549597 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11549597 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:11549597 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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