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| pubmed-article:11546806 | pubmed:issue | 47 | lld:pubmed |
| pubmed-article:11546806 | pubmed:dateCreated | 2001-11-19 | lld:pubmed |
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| pubmed-article:11546806 | pubmed:abstractText | A human protein kinase, p53-related protein kinase (PRPK), was cloned from an interleukin-2-activated cytotoxic T-cell subtraction library. PRPK appears to be a homologue of a growth-related yeast serine/threonine protein kinase, YGR262c. However, a complementation assay using YGR262c-disrupted yeast indicated that PRPK is not functionally identical to the yeast enzyme. PRPK expression was observed in interleukin-2-activated cytotoxic T-cells, some human epithelial tumor cell lines, and the testes. The intrinsic transcriptional activity of p53 was up-regulated by a transient transfection of PRPK to COS-7 cells. PRPK was shown to bind to p53 and to phosphorylate p53 at Ser-15. These results indicate that PRPK may play an important role in the cell cycle and cell apoptosis through phosphorylation of p53. | lld:pubmed |
| pubmed-article:11546806 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11546806 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11546806 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11546806 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11546806 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:11546806 | pubmed:author | pubmed-author:UedaNN | lld:pubmed |
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| pubmed-article:11546806 | pubmed:author | pubmed-author:NikawaJJ | lld:pubmed |
| pubmed-article:11546806 | pubmed:author | pubmed-author:MiyoshiAA | lld:pubmed |
| pubmed-article:11546806 | pubmed:author | pubmed-author:MatsumotoSS | lld:pubmed |
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| pubmed-article:11546806 | pubmed:author | pubmed-author:EnomotoYY | lld:pubmed |
| pubmed-article:11546806 | pubmed:author | pubmed-author:WeiSS | lld:pubmed |
| pubmed-article:11546806 | pubmed:author | pubmed-author:ShigemotoKK | lld:pubmed |
| pubmed-article:11546806 | pubmed:author | pubmed-author:HitsumotoYY | lld:pubmed |
| pubmed-article:11546806 | pubmed:author | pubmed-author:NezuKK | lld:pubmed |
| pubmed-article:11546806 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11546806 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:11546806 | pubmed:volume | 276 | lld:pubmed |
| pubmed-article:11546806 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11546806 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11546806 | pubmed:pagination | 44003-11 | lld:pubmed |
| pubmed-article:11546806 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:11546806 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11546806 | pubmed:articleTitle | Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes. | lld:pubmed |
| pubmed-article:11546806 | pubmed:affiliation | First Department of Pathology and Hygiene, Ehime University School of Medicine, Shigenobu, Ehime 791-0295, Japan. yasuhito@m.ehime-u.ac.jp | lld:pubmed |
| pubmed-article:11546806 | pubmed:publicationType | Journal Article | lld:pubmed |
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