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pubmed-article:11499026pubmed:abstractTextStudies were carried out to examine the role of phosphodiesterase(PDE) III and PDE IV in the development of tachyphylaxis of isolated guinea pig trachea to beta 2 adrenoceptor agonists. Treating trachea with salbutamol(SB) 1 mumol.L-1 for 1 h produced a 5-fold rightward shift of the SB concentration-response curve for the spasmolytic effect against methacholine-induced bronchocontraction and decreased the maximum SB-induced relaxation by 30%, i.e. induced tolerance of airway response of SB in vitro. The PDE IV inhibitor rolipram (Rol, 1 mumol.L-1, IC50), but not the PDE III inhibitor siguazodan (SK&F 94836, 1 mumol.L-1, IC50), reversed the SB tolerance. However, the protein synthesis inhibitor cycloheximide(10 mumol.L-1) did not abolish the SB tolerance. These results indicate that the SB tolerance may be related to increase in PDE IV activity.lld:pubmed
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pubmed-article:11499026pubmed:authorpubmed-author:LuY BYBlld:pubmed
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pubmed-article:11499026pubmed:authorpubmed-author:ZhouH LHLlld:pubmed
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pubmed-article:11499026pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:11499026pubmed:articleTitle[Rolipram reversed salbutamol tolerance in guinea pig trachea].lld:pubmed
pubmed-article:11499026pubmed:affiliationDepartment of Pharmacology, Zhejiang Medical University, Hangzhou 310031.lld:pubmed
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