| pubmed-article:11489754 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11489754 | lifeskim:mentions | umls-concept:C0025017 | lld:lifeskim |
| pubmed-article:11489754 | lifeskim:mentions | umls-concept:C0037369 | lld:lifeskim |
| pubmed-article:11489754 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:11489754 | lifeskim:mentions | umls-concept:C0949059 | lld:lifeskim |
| pubmed-article:11489754 | lifeskim:mentions | umls-concept:C0014628 | lld:lifeskim |
| pubmed-article:11489754 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:11489754 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:11489754 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:11489754 | lifeskim:mentions | umls-concept:C1512806 | lld:lifeskim |
| pubmed-article:11489754 | lifeskim:mentions | umls-concept:C0150312 | lld:lifeskim |
| pubmed-article:11489754 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:11489754 | pubmed:dateCreated | 2001-8-7 | lld:pubmed |
| pubmed-article:11489754 | pubmed:abstractText | Microsomal epoxide hydrolase (mEH) metabolizes polycyclic aromatic hydrocarbons, carcinogens found in cigarette smoke and cooked meat. Polymorphisms in exon 3 and exon 4 of the mEH gene have been found to alter mEH activity. We investigated the association between these polymorphisms and colorectal polyps within the Minnesota Cancer Prevention Research Unit case-control study. Cases were diagnosed with colonoscopically confirmed adenomas (n = 530) or hyperplastic polyps (n = 202); controls (n = 649) were polyp-free at colonoscopy. Smoking history and meat consumption were obtained from self-administered questionnaires before colonoscopy. mEH genotypes were determined by PCR/RFLP or oligonucleotide ligation assay. The overall risks associated with exon 3 or exon 4 polymorphisms for both adenomas and hyperplastic polyps were not statistically different from 1.0. Compared with exon 3 Tyr/Tyr, 0 pack-years, risk was highest among those with the exon 3 His/His genotype and >25 pack-years of smoking [adenoma, odds ratio (OR) = 4.9 (1.9-12.8); hyperplastic, OR = 7.7 (2.5-24.0)]. Risks were not elevated among exon 4 homozygous variants, even in the presence of heavy smoking. Fried, baked, or broiled meat intake of > or =two servings/week (high) compared with < or =one serving/week was associated with a 2-fold increase in risk of adenoma. The highest risks were seen for those with the exon 3 His/His genotype and high cooked meat intake [OR = 3.3 (1.4-7.9); reference group: Tyr/Tyr, < or = 1 serving/week). Although mEH polymorphisms are not associated with an increased risk of colorectal polyps overall, genotypes that produce a slow phenotype appear to be associated with an increased risk in the presence of smoking and high intakes of cooked meat. | lld:pubmed |
| pubmed-article:11489754 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11489754 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11489754 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11489754 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11489754 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11489754 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11489754 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11489754 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:11489754 | pubmed:issn | 1055-9965 | lld:pubmed |
| pubmed-article:11489754 | pubmed:author | pubmed-author:PotterJ DJD | lld:pubmed |
| pubmed-article:11489754 | pubmed:author | pubmed-author:BiglerJJ | lld:pubmed |
| pubmed-article:11489754 | pubmed:author | pubmed-author:FosdickLL | lld:pubmed |
| pubmed-article:11489754 | pubmed:author | pubmed-author:BostickRR | lld:pubmed |
| pubmed-article:11489754 | pubmed:author | pubmed-author:WhittonJ AJA | lld:pubmed |
| pubmed-article:11489754 | pubmed:author | pubmed-author:UlrichC MCM | lld:pubmed |
| pubmed-article:11489754 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11489754 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:11489754 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11489754 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11489754 | pubmed:pagination | 875-82 | lld:pubmed |
| pubmed-article:11489754 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:11489754 | pubmed:meshHeading | pubmed-meshheading:11489754... | lld:pubmed |
| pubmed-article:11489754 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11489754 | pubmed:articleTitle | Epoxide hydrolase Tyr113His polymorphism is associated with elevated risk of colorectal polyps in the presence of smoking and high meat intake. | lld:pubmed |
| pubmed-article:11489754 | pubmed:affiliation | Fred Hutchinson Cancer Research Center, Cancer Prevention Research Program, Seattle, Washington 98109-1024, USA. nulrich@fhcrc.org | lld:pubmed |
| pubmed-article:11489754 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:2052 | entrezgene:pubmed | pubmed-article:11489754 | lld:entrezgene |
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