| pubmed-article:11484765 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11484765 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:11484765 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:11484765 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:11484765 | lifeskim:mentions | umls-concept:C2339371 | lld:lifeskim |
| pubmed-article:11484765 | lifeskim:mentions | umls-concept:C0248868 | lld:lifeskim |
| pubmed-article:11484765 | lifeskim:mentions | umls-concept:C0001122 | lld:lifeskim |
| pubmed-article:11484765 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:11484765 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11484765 | pubmed:dateCreated | 2001-8-3 | lld:pubmed |
| pubmed-article:11484765 | pubmed:abstractText | It has been suggested that the activity of Ca2+/calmodulin-dependent protein kinase II (CaMKII) increases during acidosis in cardiac muscle. Thus we have investigated the role of CaMKII during acidosis by monitoring intracellular Ca2+ (using fura-2) and ICa (using the perforated patch clamp technique) during acidosis, in the absence and presence of the CaMKII inhibitor KN-93, in rat isolated ventricular myocytes. In the absence of KN-93, acidosis (pH 6.5) increased the amplitude of the fura-2 transient and prolonged its decay, but in the presence of KN-93 acidosis did not alter the amplitude and prolonged the decay more. In the absence of KN-93, acidosis increased the amplitude of the caffeine-induced fura-2 transient but did not alter its amplitude in the presence of KN-93. ICa did not change significantly during acidosis in the absence of KN-93 but decreased during acidosis in the presence of KN-93. These results suggest that activation of CaMKII during acidosis helps to compensate for the direct inhibitory effects of acidosis on sarcoplasmic reticular Ca2+ uptake and ICa. | lld:pubmed |
| pubmed-article:11484765 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11484765 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11484765 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11484765 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11484765 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11484765 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11484765 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11484765 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11484765 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11484765 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11484765 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11484765 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11484765 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11484765 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11484765 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11484765 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11484765 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11484765 | pubmed:issn | 0031-6768 | lld:pubmed |
| pubmed-article:11484765 | pubmed:author | pubmed-author:OrchardC HCH | lld:pubmed |
| pubmed-article:11484765 | pubmed:author | pubmed-author:PascarelCC | lld:pubmed |
| pubmed-article:11484765 | pubmed:author | pubmed-author:KomukaiKK | lld:pubmed |
| pubmed-article:11484765 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11484765 | pubmed:volume | 442 | lld:pubmed |
| pubmed-article:11484765 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11484765 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11484765 | pubmed:pagination | 353-61 | lld:pubmed |
| pubmed-article:11484765 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:11484765 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11484765 | pubmed:articleTitle | Compensatory role of CaMKII on ICa and SR function during acidosis in rat ventricular myocytes. | lld:pubmed |
| pubmed-article:11484765 | pubmed:affiliation | School of Biomedical Sciences, University of Leeds, UK. | lld:pubmed |
| pubmed-article:11484765 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11484765 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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