Linked Life Data

11469864

Source:http://linkedlifedata.com/resource/pubmed/id/11469864

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pubmed-article:11469864pubmed:abstractTextThe conformational exchange of the phosphate and deoxyribose groups of the DNA oligomers d(GCGTACGC)(2) and d(CGCTAGCG)(2) have been investigated using a combination of homonuclear and heteronuclear NMR techniques. Two-state exchange between phosphate B(I) and B(II) conformations and deoxyribose N and S conformations was expressed as percent population of the major conformer, %B(I) or %S. Sequence context-dependent variations in %B(I) and %S were observed. The positions of the phosphate and deoxyribose equilibria provide a quantitative measure of the ps to ns timescale dynamic exchange processes in the DNA backbone. Linear correlations between %B(I), %S, and previously calculated model free (13)C order parameters (S(2)) were observed. The %B(I) of the phosphates were found to be correlated to the S(2) of the flanking C3' and C4' atoms. The %B(I) was also found to be correlated with the %S and C1' S(2) of the deoxyribose ring 5' of the phosphates. The %B(I) of opposing phosphates is correlated, while the %B(I) of sequential phosphates is anti-correlated. These correlations suggest that conformational exchange processes in DNA are coupled to each other and are modulated by DNA base sequence, which may have important implications for DNA-protein interactions.lld:pubmed
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pubmed-article:11469864pubmed:authorpubmed-author:IsaacsR JRJlld:pubmed
pubmed-article:11469864pubmed:authorpubmed-author:SpielmannH...lld:pubmed
pubmed-article:11469864pubmed:copyrightInfoCopyright 2001 Academic Press.lld:pubmed
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pubmed-article:11469864pubmed:pagination149-60lld:pubmed
pubmed-article:11469864pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:11469864pubmed:articleTitleNMR evidence for mechanical coupling of phosphate B(I)-B(II) transitions with deoxyribose conformational exchange in DNA.lld:pubmed
pubmed-article:11469864pubmed:affiliationDepartment of Molecular and Cellular Biochemistry Department of Chemistry, & Kentucky Center for Structural Biology, University of Kentucky, Lexington, KY 40536-0084, USA.lld:pubmed
pubmed-article:11469864pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11469864pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed
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