| pubmed-article:11448989 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11448989 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:11448989 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:11448989 | lifeskim:mentions | umls-concept:C0008633 | lld:lifeskim |
| pubmed-article:11448989 | lifeskim:mentions | umls-concept:C0085187 | lld:lifeskim |
| pubmed-article:11448989 | lifeskim:mentions | umls-concept:C1257806 | lld:lifeskim |
| pubmed-article:11448989 | lifeskim:mentions | umls-concept:C0032403 | lld:lifeskim |
| pubmed-article:11448989 | lifeskim:mentions | umls-concept:C1444754 | lld:lifeskim |
| pubmed-article:11448989 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:11448989 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:11448989 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:11448989 | lifeskim:mentions | umls-concept:C0302167 | lld:lifeskim |
| pubmed-article:11448989 | lifeskim:mentions | umls-concept:C0444930 | lld:lifeskim |
| pubmed-article:11448989 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11448989 | pubmed:dateCreated | 2001-7-12 | lld:pubmed |
| pubmed-article:11448989 | pubmed:abstractText | Poly(ADP-ribose) polymerase (PARP)-1, a detector of single-strand breaks, plays a key role in the cellular response to DNA damage. PARP-1-deficient mice are hypersensitive to genotoxic agents and display genomic instability due to a DNA repair defect in the base excision repair pathway. A previous report suggested that PARP-1-deficient mice also had a severe telomeric dysfunction consisting of telomere shortening and increased end-to-end fusions (d'Adda di Fagagna, F., M.P. Hande, W.-M. Tong, P.M. Lansdorp, Z.-Q. Wang, and S.P. Jackson. 1999. NAT: Genet. 23:76-80). In contrast to that, and using a panoply of techniques, including quantitative telomeric (Q)-FISH, we did not find significant differences in telomere length between wild-type and PARP-1(-/)- littermate mice or PARP-1(-/)- primary cells. Similarly, there were no differences in the length of the G-strand overhang. Q-FISH and spectral karyotyping analyses of primary PARP-1(-/)- cells showed a frequency of 2 end-to-end fusions per 100 metaphases, much lower than that described previously (d'Adda di Fagagna et al., 1999). This low frequency of end-to-end fusions in PARP-1(-/)- primary cells is accordant with the absence of severe proliferative defects in PARP-1(-/)- mice. The results presented here indicate that PARP-1 does not play a major role in regulating telomere length or in telomeric end capping, and the chromosomal instability of PARP-1(-/)- primary cells can be explained by the repair defect associated to PARP-1 deficiency. Finally, no interaction between PARP-1 and the telomerase reverse transcriptase subunit, Tert, was found using the two-hybrid assay. | lld:pubmed |
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| pubmed-article:11448989 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11448989 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11448989 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11448989 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11448989 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:11448989 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:11448989 | pubmed:author | pubmed-author:de MurciaGG | lld:pubmed |
| pubmed-article:11448989 | pubmed:author | pubmed-author:BlascoM AMA | lld:pubmed |
| pubmed-article:11448989 | pubmed:author | pubmed-author:CigudosaJ CJC | lld:pubmed |
| pubmed-article:11448989 | pubmed:author | pubmed-author:Ménissier-de... | lld:pubmed |
| pubmed-article:11448989 | pubmed:author | pubmed-author:GoytisoloF... | lld:pubmed |
| pubmed-article:11448989 | pubmed:author | pubmed-author:SamperEE | lld:pubmed |
| pubmed-article:11448989 | pubmed:author | pubmed-author:González-Suár... | lld:pubmed |
| pubmed-article:11448989 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11448989 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:11448989 | pubmed:volume | 154 | lld:pubmed |
| pubmed-article:11448989 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11448989 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11448989 | pubmed:pagination | 49-60 | lld:pubmed |
| pubmed-article:11448989 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:11448989 | pubmed:meshHeading | pubmed-meshheading:11448989... | lld:pubmed |
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| pubmed-article:11448989 | pubmed:meshHeading | pubmed-meshheading:11448989... | lld:pubmed |
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| pubmed-article:11448989 | pubmed:meshHeading | pubmed-meshheading:11448989... | lld:pubmed |
