| pubmed-article:11444823 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11444823 | lifeskim:mentions | umls-concept:C1705280 | lld:lifeskim |
| pubmed-article:11444823 | lifeskim:mentions | umls-concept:C1705748 | lld:lifeskim |
| pubmed-article:11444823 | lifeskim:mentions | umls-concept:C2717940 | lld:lifeskim |
| pubmed-article:11444823 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:11444823 | lifeskim:mentions | umls-concept:C0525037 | lld:lifeskim |
| pubmed-article:11444823 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:11444823 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11444823 | lifeskim:mentions | umls-concept:C0809183 | lld:lifeskim |
| pubmed-article:11444823 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:11444823 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:11444823 | lifeskim:mentions | umls-concept:C0377261 | lld:lifeskim |
| pubmed-article:11444823 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11444823 | pubmed:dateCreated | 2001-7-10 | lld:pubmed |
| pubmed-article:11444823 | pubmed:abstractText | Saikosaponin a, a purified ingredient of Chinese herb with known antitumor activity, can inhibit cell growth and DNA synthesis of hepatoma cell line HepG2. Both mRNA and protein of the CDK inhibitor p-16(INK4a) and p-15(INK4b) in HepG2 were greatly induced by saikosaponin a while that of p-21(CIP), p-27(KIP) and other cell cycle related genes were not. In addition, reduced phosphorylation of RB protein is observed in saikosaponin a-treated HepG2. Staurosporin, one of the PKC inhibitors, significantly prevented the saikosaponin a induced growth inhibition suggesting PKC pathway be involved. On the other hand, the phorbol ester tumor promoter TPA (12-O-Tetredecanolyphorbol 13-acetate) also inhibited HepG2 growth and specifically induced p-16(INK4a) and p-15(INK4b) mRNA expression. The results suggest that both saikosaponin a and TPA-induced HepG2 growth inhibition are associated with p-15(INK4a) and p-16(INK4b) gene expression and might be mediated by PKC signaling pathway. | lld:pubmed |
| pubmed-article:11444823 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11444823 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11444823 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11444823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11444823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11444823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11444823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11444823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11444823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11444823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11444823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11444823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11444823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11444823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11444823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11444823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11444823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11444823 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11444823 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11444823 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:11444823 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:11444823 | pubmed:author | pubmed-author:HsuH YHY | lld:pubmed |
| pubmed-article:11444823 | pubmed:author | pubmed-author:RekLL | lld:pubmed |
| pubmed-article:11444823 | pubmed:copyrightInfo | Copyright 2001 Academic Press. | lld:pubmed |
| pubmed-article:11444823 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11444823 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:11444823 | pubmed:volume | 285 | lld:pubmed |
| pubmed-article:11444823 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11444823 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11444823 | pubmed:pagination | 183-7 | lld:pubmed |
| pubmed-article:11444823 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:11444823 | pubmed:meshHeading | pubmed-meshheading:11444823... | lld:pubmed |
| pubmed-article:11444823 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11444823 | pubmed:articleTitle | Involvement of p-15(INK4b) and p-16(INK4a) gene expression in saikosaponin a and TPA-induced growth inhibition of HepG2 cells. | lld:pubmed |
| pubmed-article:11444823 | pubmed:affiliation | Department of Medical Technology, Tzu Chi University, No. 701, Chung Yang Rd., Sec. 3, Hualien, Taiwan 970. wuws@mail.tcu.edu.tw | lld:pubmed |
| pubmed-article:11444823 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11444823 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
