| pubmed-article:11396475 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11396475 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:11396475 | lifeskim:mentions | umls-concept:C0003402 | lld:lifeskim |
| pubmed-article:11396475 | lifeskim:mentions | umls-concept:C0028128 | lld:lifeskim |
| pubmed-article:11396475 | lifeskim:mentions | umls-concept:C0242606 | lld:lifeskim |
| pubmed-article:11396475 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:11396475 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11396475 | pubmed:dateCreated | 2001-6-8 | lld:pubmed |
| pubmed-article:11396475 | pubmed:abstractText | Three distinct antioxidant pathways are considered through which iron-catalyzed oxidative stress may be regulated by nitric oxide (NO). The first two pathways involve direct redox interactions of NO with iron catalytic sites and represent a fast response that may be considered an emergency mechanism to protect cells from the consequences of acute and intensive oxidative stress. These are (i) NO-induced nitrosylation at heme and non-heme iron catalytic sites that is capable of directly reducing oxoferryl-associated radicals, (ii) formation of nitrosyl complexes with intracellular "loosely" bound redox-active iron, and (iii) an indirect regulatory pathway that may function as an adaptive mechanism that becomes operational upon long-term exposure of cells to NO. In the latter pathway, NO down-regulates expression of iron-containing proteins to prevent their catalytic prooxidant reactions. | lld:pubmed |
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| pubmed-article:11396475 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11396475 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11396475 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11396475 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11396475 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11396475 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11396475 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11396475 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11396475 | pubmed:issn | 1523-0864 | lld:pubmed |
| pubmed-article:11396475 | pubmed:author | pubmed-author:KaganV EVE | lld:pubmed |
| pubmed-article:11396475 | pubmed:author | pubmed-author:KozlovA VAV | lld:pubmed |
| pubmed-article:11396475 | pubmed:author | pubmed-author:ShvedovaA AAA | lld:pubmed |
| pubmed-article:11396475 | pubmed:author | pubmed-author:YalowichJ CJC | lld:pubmed |
| pubmed-article:11396475 | pubmed:author | pubmed-author:TyurinaY YYY | lld:pubmed |
| pubmed-article:11396475 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11396475 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:11396475 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11396475 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11396475 | pubmed:pagination | 189-202 | lld:pubmed |
| pubmed-article:11396475 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:11396475 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11396475 | pubmed:articleTitle | Antioxidant mechanisms of nitric oxide against iron-catalyzed oxidative stress in cells. | lld:pubmed |
| pubmed-article:11396475 | pubmed:affiliation | Department of Environmental and Occupational Health, University of Pittsburgh, PA 15238, USA. kagan@pitt.edu | lld:pubmed |
| pubmed-article:11396475 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11396475 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11396475 | pubmed:publicationType | Review | lld:pubmed |
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