| pubmed-article:11387343 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11387343 | lifeskim:mentions | umls-concept:C0080092 | lld:lifeskim |
| pubmed-article:11387343 | lifeskim:mentions | umls-concept:C0206116 | lld:lifeskim |
| pubmed-article:11387343 | lifeskim:mentions | umls-concept:C1514559 | lld:lifeskim |
| pubmed-article:11387343 | lifeskim:mentions | umls-concept:C1155266 | lld:lifeskim |
| pubmed-article:11387343 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:11387343 | pubmed:issue | 32 | lld:pubmed |
| pubmed-article:11387343 | pubmed:dateCreated | 2001-8-6 | lld:pubmed |
| pubmed-article:11387343 | pubmed:abstractText | Microglia are important in the inflammatory response in Alzheimer's disease (AD). We showed previously that macrophage colony-stimulating factor receptor (M-CSFR), encoded by the c-fms protooncogene, is overexpressed on microglia surrounding amyloid beta (Abeta) deposits in the APP(V717F) mouse model for AD. The M-CSFR is also increased on microglia after experimental brain injury and in AD. To determine the relevance of these findings, we transiently expressed M-CSFR on murine BV-2 and human SV-A3 microglial cell lines using an SV40-promoted c-fms construct. M-CSFR overexpression resulted in microglial proliferation and increased expression of inducible nitric-oxide synthase, the proinflammatory cytokines interleukin-1alpha, macrophage inflammatory protein 1-alpha, and interleukin-6 and of macrophage colony-stimulating factor (M-CSF) itself. Antibody neutralization of M-CSF showed that the M-CSFR-induced proinflammatory response was dependent on M-CSF in the culture media. By using a co-culture of c-fms-transfected murine microglia and rat organotypic hippocampal slices and a species-specific real time reverse transcriptase-polymerase chain reaction assay and enzyme-linked immunosorbent assay, we showed that M-CSFR overexpression on exogenous microglia induced expression of interleukin-1alpha by the organotypic culture. These results show that increased M-CSFR expression induces microglial proliferation, cytokine expression, and a paracrine inflammatory response, suggesting that in APP(V717F) mice increased M-CSFR on microglia could be an important factor in Abeta-induced inflammatory response. | lld:pubmed |
| pubmed-article:11387343 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11387343 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11387343 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11387343 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11387343 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11387343 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11387343 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11387343 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11387343 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11387343 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11387343 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11387343 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11387343 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11387343 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11387343 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11387343 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11387343 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11387343 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11387343 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11387343 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:11387343 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:11387343 | pubmed:author | pubmed-author:LeeY LYL | lld:pubmed |
| pubmed-article:11387343 | pubmed:author | pubmed-author:MurphyG MGMJr | lld:pubmed |
| pubmed-article:11387343 | pubmed:author | pubmed-author:PoolAA | lld:pubmed |
| pubmed-article:11387343 | pubmed:author | pubmed-author:ZhaoFF | lld:pubmed |
| pubmed-article:11387343 | pubmed:author | pubmed-author:PerezG VGV | lld:pubmed |
| pubmed-article:11387343 | pubmed:author | pubmed-author:MitrasinovicO... | lld:pubmed |
| pubmed-article:11387343 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11387343 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:11387343 | pubmed:volume | 276 | lld:pubmed |
| pubmed-article:11387343 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11387343 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11387343 | pubmed:pagination | 30142-9 | lld:pubmed |
| pubmed-article:11387343 | pubmed:dateRevised | 2011-10-27 | lld:pubmed |
| pubmed-article:11387343 | pubmed:meshHeading | pubmed-meshheading:11387343... | lld:pubmed |
| pubmed-article:11387343 | pubmed:meshHeading | pubmed-meshheading:11387343... | lld:pubmed |
| pubmed-article:11387343 | pubmed:meshHeading | pubmed-meshheading:11387343... | lld:pubmed |
| pubmed-article:11387343 | pubmed:meshHeading | pubmed-meshheading:11387343... | lld:pubmed |
| pubmed-article:11387343 | pubmed:meshHeading | pubmed-meshheading:11387343... | lld:pubmed |
| pubmed-article:11387343 | pubmed:meshHeading | pubmed-meshheading:11387343... | lld:pubmed |
| pubmed-article:11387343 | pubmed:meshHeading | pubmed-meshheading:11387343... | lld:pubmed |
| pubmed-article:11387343 | pubmed:meshHeading | pubmed-meshheading:11387343... | lld:pubmed |
| pubmed-article:11387343 | pubmed:meshHeading | pubmed-meshheading:11387343... | lld:pubmed |
| pubmed-article:11387343 | pubmed:meshHeading | pubmed-meshheading:11387343... | lld:pubmed |
| pubmed-article:11387343 | pubmed:meshHeading | pubmed-meshheading:11387343... | lld:pubmed |
| pubmed-article:11387343 | pubmed:meshHeading | pubmed-meshheading:11387343... | lld:pubmed |
| pubmed-article:11387343 | pubmed:meshHeading | pubmed-meshheading:11387343... | lld:pubmed |
| pubmed-article:11387343 | pubmed:meshHeading | pubmed-meshheading:11387343... | lld:pubmed |
| pubmed-article:11387343 | pubmed:meshHeading | pubmed-meshheading:11387343... | lld:pubmed |
| pubmed-article:11387343 | pubmed:meshHeading | pubmed-meshheading:11387343... | lld:pubmed |
| pubmed-article:11387343 | pubmed:meshHeading | pubmed-meshheading:11387343... | lld:pubmed |
| pubmed-article:11387343 | pubmed:meshHeading | pubmed-meshheading:11387343... | lld:pubmed |
| pubmed-article:11387343 | pubmed:meshHeading | pubmed-meshheading:11387343... | lld:pubmed |
| pubmed-article:11387343 | pubmed:meshHeading | pubmed-meshheading:11387343... | lld:pubmed |
| pubmed-article:11387343 | pubmed:meshHeading | pubmed-meshheading:11387343... | lld:pubmed |
| pubmed-article:11387343 | pubmed:meshHeading | pubmed-meshheading:11387343... | lld:pubmed |
| pubmed-article:11387343 | pubmed:meshHeading | pubmed-meshheading:11387343... | lld:pubmed |
| pubmed-article:11387343 | pubmed:meshHeading | pubmed-meshheading:11387343... | lld:pubmed |
| pubmed-article:11387343 | pubmed:meshHeading | pubmed-meshheading:11387343... | lld:pubmed |
| pubmed-article:11387343 | pubmed:meshHeading | pubmed-meshheading:11387343... | lld:pubmed |
| pubmed-article:11387343 | pubmed:meshHeading | pubmed-meshheading:11387343... | lld:pubmed |
| pubmed-article:11387343 | pubmed:meshHeading | pubmed-meshheading:11387343... | lld:pubmed |
| pubmed-article:11387343 | pubmed:meshHeading | pubmed-meshheading:11387343... | lld:pubmed |
| pubmed-article:11387343 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11387343 | pubmed:articleTitle | Overexpression of macrophage colony-stimulating factor receptor on microglial cells induces an inflammatory response. | lld:pubmed |
| pubmed-article:11387343 | pubmed:affiliation | Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA. | lld:pubmed |
| pubmed-article:11387343 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11387343 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11387343 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:1435 | entrezgene:pubmed | pubmed-article:11387343 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11387343 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11387343 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11387343 | lld:pubmed |
