| pubmed-article:11382775 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11382775 | lifeskim:mentions | umls-concept:C0079382 | lld:lifeskim |
| pubmed-article:11382775 | lifeskim:mentions | umls-concept:C0008051 | lld:lifeskim |
| pubmed-article:11382775 | lifeskim:mentions | umls-concept:C0081620 | lld:lifeskim |
| pubmed-article:11382775 | lifeskim:mentions | umls-concept:C0029923 | lld:lifeskim |
| pubmed-article:11382775 | lifeskim:mentions | umls-concept:C0027481 | lld:lifeskim |
| pubmed-article:11382775 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:11382775 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:11382775 | pubmed:issue | 30 | lld:pubmed |
| pubmed-article:11382775 | pubmed:dateCreated | 2001-7-23 | lld:pubmed |
| pubmed-article:11382775 | pubmed:abstractText | Friend of GATA (FOG)-2 is a multi-zinc finger transcriptional corepressor protein that binds specifically to GATA4. Gene targeting studies have demonstrated that FOG-2 is required for normal cardiac morphogenesis, including the development of the coronary vasculature, left ventricular compact zone, and heart valves. To better understand the molecular mechanisms by which FOG-2 regulates these cardiac developmental programs, we screened a mouse day 11 embryo library using a yeast two-hybrid interaction trap with the fifth and sixth zinc fingers of FOG-2 as bait. Using this approach, we isolated clones encoding the orphan nuclear receptors chicken ovalbumin upstream promoter-transcription factor (COUP-TF) 2 and COUP-TF3. COUP-TF2-null embryos die during embryonic development with defective angiogenesis and cardiac defects, a pattern that partly resembles the FOG-2-null phenotype. The interaction between COUP-TF2 and FOG-2 in mammalian cells was confirmed by co-immunoprecipitation of these proteins from transfected COS-7 cells. The sites of binding interaction between COUP-TF2 and FOG-2 were mapped to zinc fingers 5 and 6 and fingers 7 and 8 of FOG-2 and to the carboxyl terminus of the COUP-TF proteins. Binding to COUP-TF2 was specific because FOG-2 did not interact with the ligand-binding domains of retinoid X receptor alpha, glucocorticoid receptor, and peroxisome proliferating antigen receptor gamma, which are related to the COUP-TF proteins. Full-length FOG-2 markedly enhanced transcriptional repression by GAL4-COUP-TF2(117-414), but not by a COUP-TF2 repression domain mutant. Moreover, FOG-2 repressed COUP-TF2dependent synergistic activation of the atrial natriuretic factor promoter by both GATA4 and the FOG-2-independent mutant GATA4-E215K. Taken together, these findings suggest that FOG-2 functions as a corepressor for both GATA and COUP-TF proteins. | lld:pubmed |
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| pubmed-article:11382775 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11382775 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11382775 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11382775 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:11382775 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:11382775 | pubmed:author | pubmed-author:LeidenJ MJM | lld:pubmed |
| pubmed-article:11382775 | pubmed:author | pubmed-author:AikawaRR | lld:pubmed |
| pubmed-article:11382775 | pubmed:author | pubmed-author:BoltaxJJ | lld:pubmed |
| pubmed-article:11382775 | pubmed:author | pubmed-author:HugginsG SGS | lld:pubmed |
| pubmed-article:11382775 | pubmed:author | pubmed-author:BacaniC JCJ | lld:pubmed |
| pubmed-article:11382775 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11382775 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:11382775 | pubmed:volume | 276 | lld:pubmed |
| pubmed-article:11382775 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11382775 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11382775 | pubmed:pagination | 28029-36 | lld:pubmed |
| pubmed-article:11382775 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:11382775 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11382775 | pubmed:articleTitle | Friend of GATA 2 physically interacts with chicken ovalbumin upstream promoter-TF2 (COUP-TF2) and COUP-TF3 and represses COUP-TF2-dependent activation of the atrial natriuretic factor promoter. | lld:pubmed |
| pubmed-article:11382775 | pubmed:affiliation | Cardiovascular Biology Laboratory, Harvard School of Public Health, Cardiac Unit, Massachusetts General Hospital, USA. huggins@cvlab.harvard.edu | lld:pubmed |
| pubmed-article:11382775 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11382775 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11382775 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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