| pubmed-article:11329451 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11329451 | lifeskim:mentions | umls-concept:C0086300 | lld:lifeskim |
| pubmed-article:11329451 | lifeskim:mentions | umls-concept:C0023767 | lld:lifeskim |
| pubmed-article:11329451 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:11329451 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:11329451 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:11329451 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11329451 | pubmed:dateCreated | 2001-5-1 | lld:pubmed |
| pubmed-article:11329451 | pubmed:abstractText | The biological properties of the lipid A from Flavobacterium meningosepticum, which we recently isolated and whose complete chemical structure has been determined (H. Kato, T. Iida, Y. Haishima, A. Tanaka, and K. Tanamoto. J. Bacteriol. 180:3891--3899, 1998), were studied. The lipid A exhibited generally moderate activity compared to Salmonella enterica subsp. enterica serovar abortus equi lipopolysaccharide (LPS) used as a control in the assay systems tested; lethal toxicity in galactosamine-sensitized mice, mitogenicity in mouse spleen cells, induction of tumor necrosis factor alpha (TNF-alpha) release from mouse peritoneal macrophages and J774-1 mouse macrophage-like and human THP-1 line cells, nitric oxide induction activity from J774-1 cells, and Limulus gelation activity. The moderate activity of the F. meningosepticum lipid A may be explained by its unique fatty acid composition and the lack of a phosphate group in position 4'. It is noteworthy that the lipid A apparently induced TNF-alpha release from peritoneal macrophages in LPS-unresponsive C3H/HeJ mice and that the activation was suppressed by the LPS-specific antagonist, succinylated lipid A precursor. Significant splenocyte mitogenicity in C3H/HeJ mice was also observed with the lipid A. Taken together with the previous results concerning Porphyromonas gingivalis lipid A, which has a high level of structural similarity to the lipid A of F. meningosepticum, and the induction of TNF-alpha release in macrophages from C3H/HeJ mice, the lipid A of F. meningosepticum, which has novel fatty acids, may possibly play an role for the activation of C3H/HeJ macrophages. | lld:pubmed |
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| pubmed-article:11329451 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11329451 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11329451 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11329451 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11329451 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11329451 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11329451 | pubmed:month | May | lld:pubmed |
| pubmed-article:11329451 | pubmed:issn | 1071-412X | lld:pubmed |
| pubmed-article:11329451 | pubmed:author | pubmed-author:KatzEE | lld:pubmed |
| pubmed-article:11329451 | pubmed:author | pubmed-author:TanamotoKK | lld:pubmed |
| pubmed-article:11329451 | pubmed:author | pubmed-author:AzumiSS | lld:pubmed |
| pubmed-article:11329451 | pubmed:author | pubmed-author:HaishimaYY | lld:pubmed |
| pubmed-article:11329451 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11329451 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:11329451 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11329451 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11329451 | pubmed:pagination | 522-7 | lld:pubmed |
| pubmed-article:11329451 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:11329451 | pubmed:meshHeading | pubmed-meshheading:11329451... | lld:pubmed |
| pubmed-article:11329451 | pubmed:meshHeading | pubmed-meshheading:11329451... | lld:pubmed |
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| pubmed-article:11329451 | pubmed:meshHeading | pubmed-meshheading:11329451... | lld:pubmed |
| pubmed-article:11329451 | pubmed:meshHeading | pubmed-meshheading:11329451... | lld:pubmed |
| pubmed-article:11329451 | pubmed:meshHeading | pubmed-meshheading:11329451... | lld:pubmed |
| pubmed-article:11329451 | pubmed:meshHeading | pubmed-meshheading:11329451... | lld:pubmed |
| pubmed-article:11329451 | pubmed:meshHeading | pubmed-meshheading:11329451... | lld:pubmed |
| pubmed-article:11329451 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11329451 | pubmed:articleTitle | Biological properties of lipid A isolated from Flavobacterium meningosepticum. | lld:pubmed |
| pubmed-article:11329451 | pubmed:affiliation | Division of Microbiology, National Institute of Health Sciences, Tokyo 158-8501, Japan. tanamoto@nihs.go.jp | lld:pubmed |
| pubmed-article:11329451 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11329451 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
