Linked Life Data

11329179

Source:http://linkedlifedata.com/resource/pubmed/id/11329179

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:11329179rdf:typepubmed:Citationlld:pubmed
pubmed-article:11329179lifeskim:mentionsumls-concept:C0019704lld:lifeskim
pubmed-article:11329179lifeskim:mentionsumls-concept:C0021311lld:lifeskim
pubmed-article:11329179lifeskim:mentionsumls-concept:C0086418lld:lifeskim
pubmed-article:11329179lifeskim:mentionsumls-concept:C0004112lld:lifeskim
pubmed-article:11329179lifeskim:mentionsumls-concept:C0080194lld:lifeskim
pubmed-article:11329179lifeskim:mentionsumls-concept:C0524914lld:lifeskim
pubmed-article:11329179lifeskim:mentionsumls-concept:C0205245lld:lifeskim
pubmed-article:11329179lifeskim:mentionsumls-concept:C0205409lld:lifeskim
pubmed-article:11329179lifeskim:mentionsumls-concept:C1332823lld:lifeskim
pubmed-article:11329179lifeskim:mentionsumls-concept:C1332700lld:lifeskim
pubmed-article:11329179lifeskim:mentionsumls-concept:C0017262lld:lifeskim
pubmed-article:11329179lifeskim:mentionsumls-concept:C0231204lld:lifeskim
pubmed-article:11329179lifeskim:mentionsumls-concept:C2911684lld:lifeskim
pubmed-article:11329179lifeskim:mentionsumls-concept:C0185117lld:lifeskim
pubmed-article:11329179pubmed:issue3lld:pubmed
pubmed-article:11329179pubmed:dateCreated2001-4-30lld:pubmed
pubmed-article:11329179pubmed:abstractTextWithin the brain, HIV-1 targets the microglia and astrocytes. Previous studies have reported that viral entry into astrocytes is independent of CD4, in contrast to microglia. We aimed to determine whether chemokine receptors play a role in mediating CD4-independent HIV-1 entry into astrocytes. We found that embryonic astrocytes and microglial cells express CCR5, CCR3, and CXCR4 transcripts. Intracellular calcium levels in astrocytes were found to increase following application of RANTES, MIP-1beta (CCR5-agonist), SDF-1alpha (CXCR4-agonist), but not eotaxin (CCR3-agonist). In microglial cells, eotaxin was also able to modulate internal calcium homeostasis. CD4 was not present at the cell surface of purified astrocytes but CD4 mRNA could be detected by RT-PCR. Neither HIV-1(9533) (R5 isolate) nor HIV-1(LAI) (X4 isolate) penetrated into purified astrocytes. In contrast, mixed CNS cell cultures were infected by HIV-1(9533) and this was inhibited by anti-CD4 mAb in 4/4 tested cultures and by anti-CCR5 mAb in 2/4. Thus, the HIV-1 R5 strain requires CD4 to penetrate into brain cells, suggesting that CCR5 cannot be used as the primary receptor for M-tropic HIV-1 strains in astrocytes. Moreover, inconstant inhibition of HIV-1 entry by anti-CCR5 mAb supports the existence of alternative coreceptors for penetration of M-tropic isolates into brain cells.lld:pubmed
pubmed-article:11329179pubmed:languageenglld:pubmed
pubmed-article:11329179pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11329179pubmed:citationSubsetIMlld:pubmed
pubmed-article:11329179pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11329179pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11329179pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11329179pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11329179pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11329179pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11329179pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11329179pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11329179pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11329179pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11329179pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11329179pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11329179pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11329179pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:11329179pubmed:statusMEDLINElld:pubmed
pubmed-article:11329179pubmed:monthMaylld:pubmed
pubmed-article:11329179pubmed:issn0894-1491lld:pubmed
pubmed-article:11329179pubmed:authorpubmed-author:VincentJ DJDlld:pubmed
pubmed-article:11329179pubmed:authorpubmed-author:TardieuMMlld:pubmed
pubmed-article:11329179pubmed:authorpubmed-author:DelfraissyJ...lld:pubmed
pubmed-article:11329179pubmed:authorpubmed-author:SalisBBlld:pubmed
pubmed-article:11329179pubmed:authorpubmed-author:LledoP MPMlld:pubmed
pubmed-article:11329179pubmed:authorpubmed-author:BoutetAAlld:pubmed
pubmed-article:11329179pubmed:authorpubmed-author:TaoufikYYlld:pubmed
pubmed-article:11329179pubmed:copyrightInfoCopyright 2001 Wiley-Liss, Inc.lld:pubmed
pubmed-article:11329179pubmed:issnTypePrintlld:pubmed
pubmed-article:11329179pubmed:volume34lld:pubmed
pubmed-article:11329179pubmed:ownerNLMlld:pubmed
pubmed-article:11329179pubmed:authorsCompleteYlld:pubmed
pubmed-article:11329179pubmed:pagination165-77lld:pubmed
pubmed-article:11329179pubmed:dateRevised2007-11-15lld:pubmed
pubmed-article:11329179pubmed:meshHeadingpubmed-meshheading:11329179...lld:pubmed
pubmed-article:11329179pubmed:meshHeadingpubmed-meshheading:11329179...lld:pubmed
pubmed-article:11329179pubmed:meshHeadingpubmed-meshheading:11329179...lld:pubmed
pubmed-article:11329179pubmed:meshHeadingpubmed-meshheading:11329179...lld:pubmed
pubmed-article:11329179pubmed:meshHeadingpubmed-meshheading:11329179...lld:pubmed
pubmed-article:11329179pubmed:meshHeadingpubmed-meshheading:11329179...lld:pubmed
pubmed-article:11329179pubmed:meshHeadingpubmed-meshheading:11329179...lld:pubmed
pubmed-article:11329179pubmed:meshHeadingpubmed-meshheading:11329179...lld:pubmed
pubmed-article:11329179pubmed:meshHeadingpubmed-meshheading:11329179...lld:pubmed
pubmed-article:11329179pubmed:meshHeadingpubmed-meshheading:11329179...lld:pubmed
pubmed-article:11329179pubmed:meshHeadingpubmed-meshheading:11329179...lld:pubmed
pubmed-article:11329179pubmed:meshHeadingpubmed-meshheading:11329179...lld:pubmed
pubmed-article:11329179pubmed:meshHeadingpubmed-meshheading:11329179...lld:pubmed
pubmed-article:11329179pubmed:meshHeadingpubmed-meshheading:11329179...lld:pubmed
pubmed-article:11329179pubmed:meshHeadingpubmed-meshheading:11329179...lld:pubmed
pubmed-article:11329179pubmed:meshHeadingpubmed-meshheading:11329179...lld:pubmed
pubmed-article:11329179pubmed:meshHeadingpubmed-meshheading:11329179...lld:pubmed
pubmed-article:11329179pubmed:meshHeadingpubmed-meshheading:11329179...lld:pubmed
pubmed-article:11329179pubmed:meshHeadingpubmed-meshheading:11329179...lld:pubmed
pubmed-article:11329179pubmed:meshHeadingpubmed-meshheading:11329179...lld:pubmed
pubmed-article:11329179pubmed:meshHeadingpubmed-meshheading:11329179...lld:pubmed
pubmed-article:11329179pubmed:meshHeadingpubmed-meshheading:11329179...lld:pubmed
pubmed-article:11329179pubmed:meshHeadingpubmed-meshheading:11329179...lld:pubmed
pubmed-article:11329179pubmed:meshHeadingpubmed-meshheading:11329179...lld:pubmed
pubmed-article:11329179pubmed:meshHeadingpubmed-meshheading:11329179...lld:pubmed
pubmed-article:11329179pubmed:meshHeadingpubmed-meshheading:11329179...lld:pubmed
pubmed-article:11329179pubmed:year2001lld:pubmed
pubmed-article:11329179pubmed:articleTitleIsolated human astrocytes are not susceptible to infection by M- and T-tropic HIV-1 strains despite functional expression of the chemokine receptors CCR5 and CXCR4.lld:pubmed
pubmed-article:11329179pubmed:affiliationLaboratoire d'immunologie antivirale systémique et cérébrale, Inserm E 0109, Faculté de Médecine Paris-Sud, Le Kremlin-Bicêtre Cedex, France. agnes.boutet@kb.u-psud.frlld:pubmed
pubmed-article:11329179pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11329179pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11329179lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11329179lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11329179lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11329179lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11329179lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11329179lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11329179lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:11329179lld:pubmed