| pubmed-article:11324549 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11324549 | lifeskim:mentions | umls-concept:C0034709 | lld:lifeskim |
| pubmed-article:11324549 | lifeskim:mentions | umls-concept:C0031453 | lld:lifeskim |
| pubmed-article:11324549 | lifeskim:mentions | umls-concept:C1658578 | lld:lifeskim |
| pubmed-article:11324549 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:11324549 | pubmed:dateCreated | 2001-4-27 | lld:pubmed |
| pubmed-article:11324549 | pubmed:abstractText | Cell growth and proliferation were evaluated in cultured vascular smooth muscle cells (VSMCs) isolated from spontaneously hypertensive rat (SHR) and normotensive Wistar-Kyoto (WKY) rat aortae by measuring [3H]-thymidine incorporation into newly synthesized DNA and by determining cell number, respectively. The results showed that in cultures from both rat strains (1) serum-, basic fibroblast growth factor (bFGF)- and thrombin-induced DNA synthesis were inhibited by L-phenylalanine dose-dependently; (2) L-phenylalanine inhibited cell proliferation in response to serum in a concentration-dependent manner; (3) L-phenylalanine inhibited serum-induced proto-oncogene c-fos and c-myc expression; (4) L-tyrosine, L-histidine and D-phenylalanine failed to mimic the inhibitory effect of L-phenylalanine. All these data demonstrate that L-phenylalanine could exert a direct and specific antiproliferative effect on VSMCs suggesting that such effect can account for the antihypertensive action of this amino acid observed in SHR. | lld:pubmed |
| pubmed-article:11324549 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11324549 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11324549 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11324549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11324549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11324549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11324549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11324549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11324549 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11324549 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:11324549 | pubmed:issn | 0371-0874 | lld:pubmed |
| pubmed-article:11324549 | pubmed:author | pubmed-author:MarchePP | lld:pubmed |
| pubmed-article:11324549 | pubmed:author | pubmed-author:ZhaoG SGS | lld:pubmed |
| pubmed-article:11324549 | pubmed:author | pubmed-author:KauD LDL | lld:pubmed |
| pubmed-article:11324549 | pubmed:author | pubmed-author:ZhaoY HYH | lld:pubmed |
| pubmed-article:11324549 | pubmed:author | pubmed-author:ZhuD LDL | lld:pubmed |
| pubmed-article:11324549 | pubmed:author | pubmed-author:StepienOO | lld:pubmed |
| pubmed-article:11324549 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11324549 | pubmed:volume | 50 | lld:pubmed |
| pubmed-article:11324549 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11324549 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11324549 | pubmed:pagination | 401-8 | lld:pubmed |
| pubmed-article:11324549 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11324549 | pubmed:meshHeading | pubmed-meshheading:11324549... | lld:pubmed |
| pubmed-article:11324549 | pubmed:meshHeading | pubmed-meshheading:11324549... | lld:pubmed |
| pubmed-article:11324549 | pubmed:meshHeading | pubmed-meshheading:11324549... | lld:pubmed |
| pubmed-article:11324549 | pubmed:meshHeading | pubmed-meshheading:11324549... | lld:pubmed |
| pubmed-article:11324549 | pubmed:meshHeading | pubmed-meshheading:11324549... | lld:pubmed |
| pubmed-article:11324549 | pubmed:meshHeading | pubmed-meshheading:11324549... | lld:pubmed |
| pubmed-article:11324549 | pubmed:meshHeading | pubmed-meshheading:11324549... | lld:pubmed |
| pubmed-article:11324549 | pubmed:meshHeading | pubmed-meshheading:11324549... | lld:pubmed |
| pubmed-article:11324549 | pubmed:meshHeading | pubmed-meshheading:11324549... | lld:pubmed |
| pubmed-article:11324549 | pubmed:meshHeading | pubmed-meshheading:11324549... | lld:pubmed |
| pubmed-article:11324549 | pubmed:meshHeading | pubmed-meshheading:11324549... | lld:pubmed |
| pubmed-article:11324549 | pubmed:meshHeading | pubmed-meshheading:11324549... | lld:pubmed |
| pubmed-article:11324549 | pubmed:meshHeading | pubmed-meshheading:11324549... | lld:pubmed |
| pubmed-article:11324549 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:11324549 | pubmed:articleTitle | L-phenylalanine and smooth muscle cell proliferation from SHR and WKY rats. | lld:pubmed |
| pubmed-article:11324549 | pubmed:affiliation | Affiliated Ruijin Hospital and Shanghai Institute of Hypertension, Shanghai Second Medical University, Shanghai 200025, China. | lld:pubmed |
| pubmed-article:11324549 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11324549 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
